Document Detail


Catabolite control of Escherichia coli regulatory protein BglG activity by antagonistically acting phosphorylations.
MedLine Citation:
PMID:  10369677     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In bacteria various sugars are taken up and concomitantly phosphorylated by sugar-specific enzymes II (EII) of the phosphoenolpyruvate:sugar phosphotransferase system (PTS). The phosphoryl groups are donated by the phosphocarrier protein HPr. BglG, the positively acting regulatory protein of the Escherichia coli bgl (beta-glucoside utilization) operon, is known to be negatively regulated by reversible phosphorylation catalyzed by the membrane spanning beta-glucoside-specific EIIBgl. Here we present evidence that in addition BglG must be phosphorylated by HPr at a distinct site to gain activity. Our data suggest that this second, shortcut route of phosphorylation is used to monitor the state of the various PTS sugar availabilities in order to hierarchically tune expression of the bgl operon in a physiologically meaningful way. Thus, the PTS may represent a highly integrated signal transduction network in carbon catabolite control.
Authors:
B Görke; B Rak
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The EMBO journal     Volume:  18     ISSN:  0261-4189     ISO Abbreviation:  EMBO J.     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-08-19     Completed Date:  1999-08-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8208664     Medline TA:  EMBO J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  3370-9     Citation Subset:  IM    
Affiliation:
Institut für Biologie III, Universität, Schänzlestrasse 1, D-79104 Freiburg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Bacterial Proteins / antagonists & inhibitors,  chemistry,  genetics,  metabolism*
Benzyl Alcohols / metabolism
Biological Transport
Carbohydrate Metabolism
Carbon / metabolism
Carrier Proteins / genetics,  metabolism
Down-Regulation
Escherichia coli / enzymology,  genetics,  growth & development,  metabolism*
Escherichia coli Proteins*
Gene Expression Regulation, Bacterial*
Genetic Complementation Test
Isopropyl Thiogalactoside
Models, Biological
Mutation
Operon / genetics
Phosphates / metabolism
Phosphoenolpyruvate Sugar Phosphotransferase System / genetics,  metabolism
Phosphorylation
RNA-Binding Proteins / antagonists & inhibitors,  chemistry,  genetics,  metabolism*
Signal Transduction
Terminator Regions, Genetic / genetics
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/Benzyl Alcohols; 0/Carrier Proteins; 0/Escherichia coli Proteins; 0/Phosphates; 0/RNA-Binding Proteins; 0/antiterminator proteins, Bacteria; 0/fruB protein, E coli; 0/fructose-induced HPr-like protein, bacteria; 138-52-3/salicin; 367-93-1/Isopropyl Thiogalactoside; 7440-44-0/Carbon; EC 2.7.1.-/Phosphoenolpyruvate Sugar Phosphotransferase System; EC 2.7.1.-/phosphocarrier protein HPr
Comments/Corrections

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