Document Detail

Catabolism of adenine nucleotides favors adenosine production following exercise in patients with chronic heart failure.
MedLine Citation:
PMID:  17174234     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Adenosine 5'-triphosphate is catabolized to adenosine 5'-monophosphate (AMP), which is further degraded by 2 pathways: deamination to inosine 5'-monophosphate and ammonia by AMP deaminase, or dephosphorylation to adenosine and inorganic phosphate by 5'-nucleotidase. Because adenosine is believed to be cardioprotective and we have reported that ammonia production decreased after exercise in patients with chronic heart failure (CHF), we determined if plasma adenosine levels after exercise increases in patients with CHF. METHODS AND RESULTS: Maximal ergometer exercise tests with expired gas analysis were performed in 51 patients with CHF (age = 61 +/- 2 years, New York Heart Association [NYHA] class I/II/III = 19/18/14) and 20 age-matched normal controls. Serial changes in both plasma ammonia and adenosine levels were determined. The ratio for delta ammonia to peak work rate became smaller (control, NYHA I/II/III: 0.59 +/- 0.13/0.41 +/- 0.06/0.37 +/- 0.10/0.22 +/- 0.11 microg/dL x watts, respectively) and the ratio for delta adenosine to peak work rate was significantly higher in class III CHF (control, NYHA I/II/III: 0.93 +/- 0.21/0.86 +/- 0.14/1.11 +/- 0.27/2.92 +/- 0.67 nmol/L x watts, respectively). CONCLUSION: In patients with CHF after exercise, the plasma levels of adenosine increased along with the decrease in the plasma levels of ammonia. Considering the physiologic cardioprotective actions of adenosine, the enhanced adenosine production after exercise may be an important adaptive response in patients with CHF.
Toru Kinugawa; Masashi Fujita; Kazuhide Ogino; Masahiko Kato; Shuichi Osaki; Osamu Igawa; Chiaki Shigemasa; Ichiro Hisatome; Masafumi Kitakaze
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiac failure     Volume:  12     ISSN:  1532-8414     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-18     Completed Date:  2007-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  720-5     Citation Subset:  IM    
Department of Cardiovascular Medicine, Faculty of Medicine, Graduate School of Medicine, Tottori University, Yonago, Japan.
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MeSH Terms
Adenine Nucleotides / metabolism*
Adenosine / biosynthesis*,  blood
Ammonia / blood
Blood Pressure
Cardiac Output, Low / blood,  metabolism,  physiopathology*
Cardiotonic Agents / blood,  metabolism*
Chronic Disease
Heart / physiopathology
Heart Rate
Hypoxanthine / blood
Lung / physiopathology
Middle Aged
Oxygen Consumption
Reg. No./Substance:
0/Adenine Nucleotides; 0/Cardiotonic Agents; 58-61-7/Adenosine; 68-94-0/Hypoxanthine; 7664-41-7/Ammonia

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