| Catabolism of adenine nucleotides favors adenosine production following exercise in patients with chronic heart failure. | |
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MedLine Citation:
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PMID: 17174234 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Adenosine 5'-triphosphate is catabolized to adenosine 5'-monophosphate (AMP), which is further degraded by 2 pathways: deamination to inosine 5'-monophosphate and ammonia by AMP deaminase, or dephosphorylation to adenosine and inorganic phosphate by 5'-nucleotidase. Because adenosine is believed to be cardioprotective and we have reported that ammonia production decreased after exercise in patients with chronic heart failure (CHF), we determined if plasma adenosine levels after exercise increases in patients with CHF. METHODS AND RESULTS: Maximal ergometer exercise tests with expired gas analysis were performed in 51 patients with CHF (age = 61 +/- 2 years, New York Heart Association [NYHA] class I/II/III = 19/18/14) and 20 age-matched normal controls. Serial changes in both plasma ammonia and adenosine levels were determined. The ratio for delta ammonia to peak work rate became smaller (control, NYHA I/II/III: 0.59 +/- 0.13/0.41 +/- 0.06/0.37 +/- 0.10/0.22 +/- 0.11 microg/dL x watts, respectively) and the ratio for delta adenosine to peak work rate was significantly higher in class III CHF (control, NYHA I/II/III: 0.93 +/- 0.21/0.86 +/- 0.14/1.11 +/- 0.27/2.92 +/- 0.67 nmol/L x watts, respectively). CONCLUSION: In patients with CHF after exercise, the plasma levels of adenosine increased along with the decrease in the plasma levels of ammonia. Considering the physiologic cardioprotective actions of adenosine, the enhanced adenosine production after exercise may be an important adaptive response in patients with CHF. |
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Authors:
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Toru Kinugawa; Masashi Fujita; Kazuhide Ogino; Masahiko Kato; Shuichi Osaki; Osamu Igawa; Chiaki Shigemasa; Ichiro Hisatome; Masafumi Kitakaze |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiac failure Volume: 12 ISSN: 1532-8414 ISO Abbreviation: J. Card. Fail. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-18 Completed Date: 2007-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9442138 Medline TA: J Card Fail Country: United States |
Other Details:
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Languages: eng Pagination: 720-5 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, Faculty of Medicine, Graduate School of Medicine, Tottori University, Yonago, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenine Nucleotides
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metabolism* Adenosine / biosynthesis*, blood Aged Ammonia / blood Blood Pressure Cardiac Output, Low / blood, metabolism, physiopathology* Cardiotonic Agents / blood, metabolism* Chronic Disease Exercise* Female Heart / physiopathology Heart Rate Humans Hypoxanthine / blood Lung / physiopathology Male Middle Aged Oxygen Consumption |
| Chemical | |
Reg. No./Substance:
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0/Adenine Nucleotides; 0/Cardiotonic Agents; 58-61-7/Adenosine; 68-94-0/Hypoxanthine; 7664-41-7/Ammonia |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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