Document Detail


Catabolic pathway for the production of skatole and indoleacetic acid by the acetogen Clostridium drakei, Clostridium scatologenes, and swine manure.
MedLine Citation:
PMID:  18223109     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Skatole (3-methylindole) is a malodorous chemical in stored swine manure and is implicated as a component of foul-tasting pork. Definitive evidence for the skatole pathway is lacking. Deuterium-labeled substrates were employed to resolve this pathway in the acetogenic bacterium Clostridium drakei and Clostridium scatologenes and to determine if a similar pathway is used by microorganisms present in stored swine manure. Indoleacetic acid (IAA) was synthesized from tryptophan by both bacteria, and skatole was synthesized from both IAA and tryptophan. Microorganisms in swine manure produced skatole and other oxidation products from tryptophan, but IAA yielded only skatole. A catabolic mechanism for the synthesis of skatole is proposed.
Authors:
Terence R Whitehead; Neil P Price; Harold L Drake; Michael A Cotta
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Publication Detail:
Type:  Journal Article     Date:  2008-01-25
Journal Detail:
Title:  Applied and environmental microbiology     Volume:  74     ISSN:  1098-5336     ISO Abbreviation:  Appl. Environ. Microbiol.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-10     Completed Date:  2008-07-21     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  7605801     Medline TA:  Appl Environ Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1950-3     Citation Subset:  IM    
Affiliation:
Fermentation Biotechnology Research Unit, National Center for Agricultural Utilization Research, USDA, Agricultural Research Service, 1815 N. University St., Peoria, Illinois 61604, USA. terry.whitehead@ars.usda.gov
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MeSH Terms
Descriptor/Qualifier:
Animals
Clostridium / metabolism*
Gas Chromatography-Mass Spectrometry
Indoleacetic Acids / chemistry,  metabolism*
Manure / microbiology*
Molecular Structure
Skatole / chemistry,  metabolism*
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Swine
Tryptophan / chemistry,  metabolism
Chemical
Reg. No./Substance:
0/Indoleacetic Acids; 0/Manure; 6U1S09C61L/indoleacetic acid; 73-22-3/Tryptophan; 83-34-1/Skatole
Comments/Corrections

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