| Catabolic hormones alone fail to reproduce the stress-induced efflux of amino acids. | |
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MedLine Citation:
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PMID: 8048851 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the impact of catabolic hormones on the pattern of amino acid efflux from human skeletal muscle during stress. DESIGN: Cohort analytical study. SETTING: Burn intensive care unit and clinical research facility at a university hospital. PATIENTS: Five patients with severe burns and five healthy volunteers of similar size and age. INTERVENTIONS AND MEASUREMENTS: The net balance of amino acids across the leg was determined in five healthy volunteers prior to and following a 2-hour infusion of the catabolic hormones epinephrine, cortisol, and glucagon into the femoral artery. These results were compared with amino acid net balance measurements in five severely burned patients. RESULTS: Hormonal simulation of stress in the normal volunteers increased glutamine efflux from the leg to an extent similar to that of the burn patients. Alanine efflux, however, was not affected by the hormonal infusion. Because alanine efflux constituted a major proportion of the total peripheral amino acid catabolism in the burn patients, there was significantly less total amino acid nitrogen loss from the healthy volunteers receiving the stress hormones. CONCLUSIONS: Catabolic hormones alone fail to reproduce the stress-induced pattern and quantity of amino acid efflux from human skeletal muscle. This discrepancy is largely due to an unresponsiveness of alanine to hormonally induced muscle protein catabolism. |
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Authors:
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J A Brown; D C Gore; F Jahoor |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Archives of surgery (Chicago, Ill. : 1960) Volume: 129 ISSN: 0004-0010 ISO Abbreviation: Arch Surg Publication Date: 1994 Aug |
Date Detail:
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Created Date: 1994-08-30 Completed Date: 1994-08-30 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9716528 Medline TA: Arch Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 819-24 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Medical College of Virginia, Richmond. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alanine / metabolism Amino Acids / drug effects, metabolism* Burns / metabolism* Energy Metabolism Epinephrine / pharmacology Glucagon / pharmacology Hormones / pharmacology* Humans Hydrocortisone / pharmacology Male Muscles / drug effects, metabolism* Stress, Physiological / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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M01-RR00065/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Hormones; 50-23-7/Hydrocortisone; 51-43-4/Epinephrine; 56-41-7/Alanine; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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