| Catabolic effect in premature infants with early dexamethasone treatment. | |
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MedLine Citation:
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PMID: 9001663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate the catabolic effects of dexamethasone therapy on protein metabolism, amino acid concentrations and urinary 3-methylhistidine (3MH) were measured in 28 premature infants who were included in a double-blind controlled study using early dexamethasone therapy in the prevention of bronchopulmonary dysplasia. Fifteen infants received dexamethasone (0.5 mg/kg/day i.v.) and 13 infants received normal saline as control. Heparinized venous blood samples for amino acid analysis were obtained before the study and again at day 5 after starting the study. Urinary 3MH was measured on days 1, 3, 5, 7, 14, 21, and 28 of treatment. A substantial increase in amino acid concentrations was observed in infants receiving dexamethasone. Alanine, glutamine, citrulline, ornithine and cystine concentrations increased twofold or more. The 3MH:creatinine ratio was increased in the treated group. These metabolic effects were most likely due to an increase in protein catabolism. |
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Authors:
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F J Tsai; C H Tsai; S F Wu; Y H Liu; T F Yeh |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 85 ISSN: 0803-5253 ISO Abbreviation: Acta Paediatr. Publication Date: 1996 Dec |
Date Detail:
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Created Date: 1997-04-03 Completed Date: 1997-04-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: NORWAY |
Other Details:
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Languages: eng Pagination: 1487-90 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, China Medical College Hospital, Taichung, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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blood Bronchopulmonary Dysplasia / prevention & control Creatinine / urine Dexamethasone / administration & dosage, adverse effects* Double-Blind Method Female Humans Infant, Newborn Male Methylhistidines / urine Proteins / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Methylhistidines; 0/Proteins; 368-16-1/3-methylhistidine; 50-02-2/Dexamethasone; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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