Document Detail

Catabolic effect in premature infants with early dexamethasone treatment.
MedLine Citation:
PMID:  9001663     Owner:  NLM     Status:  MEDLINE    
To evaluate the catabolic effects of dexamethasone therapy on protein metabolism, amino acid concentrations and urinary 3-methylhistidine (3MH) were measured in 28 premature infants who were included in a double-blind controlled study using early dexamethasone therapy in the prevention of bronchopulmonary dysplasia. Fifteen infants received dexamethasone (0.5 mg/kg/day i.v.) and 13 infants received normal saline as control. Heparinized venous blood samples for amino acid analysis were obtained before the study and again at day 5 after starting the study. Urinary 3MH was measured on days 1, 3, 5, 7, 14, 21, and 28 of treatment. A substantial increase in amino acid concentrations was observed in infants receiving dexamethasone. Alanine, glutamine, citrulline, ornithine and cystine concentrations increased twofold or more. The 3MH:creatinine ratio was increased in the treated group. These metabolic effects were most likely due to an increase in protein catabolism.
F J Tsai; C H Tsai; S F Wu; Y H Liu; T F Yeh
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  85     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-04-03     Completed Date:  1997-04-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  1487-90     Citation Subset:  IM    
Department of Pediatrics, China Medical College Hospital, Taichung, Taiwan.
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MeSH Terms
Amino Acids / blood
Bronchopulmonary Dysplasia / prevention & control
Creatinine / urine
Dexamethasone / administration & dosage,  adverse effects*
Double-Blind Method
Infant, Newborn
Methylhistidines / urine
Proteins / metabolism*
Reg. No./Substance:
0/Amino Acids; 0/Methylhistidines; 0/Proteins; 368-16-1/3-methylhistidine; 50-02-2/Dexamethasone; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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