| Cat brain cytochrome-c oxidase redox changes induced by hypoxia after blood-fluorocarbon exchange transfusion. | |
| | |
MedLine Citation:
|
PMID: 7653605 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We used rapid-scanning near-infrared (NIR) spectroscopy (730-960 nm) to study the effects of graded or acute hypoxia on cerebral cytochrome-c oxidase (cyt aa3) redox state in blood-perfluoro-carbon-exchanged cats with somatosensory evoked potential (SEP) monitoring. In graded hypoxia [10 min each at fractional inspiratory O2 concentration (FIO2) 0.9, 0.8, 0.7, 0.6, and 0.5], cyt aa3 reduction occurred at FIO2 0.6 when cerebral O2 delivery was < 3.5 ml.100 g-1.min-1. In acute hypoxia (FIO2 0.6 for 10 min), significant cyt aa3 reduction occurred from 5 to 10 min (cerebral O2 delivery 3.1 +/- 0.3 ml.100 g-1.min-1) and recovered with reoxygenation (FIO2 1.0). Cyt aa3 redox changes preceded or coincided with SEP alterations in both hypoxia protocols. These results demonstrate that cerebral cyt aa3 reduction occurs with severe reduction of cerebral O2 delivery, but no significant change in cerebral cyt aa3 redox state occurs with small reductions of cerebral O2 delivery. We conclude that substantial changes in cerebral cyt aa3 do not occur at physiological levels of O2 delivery and that current NIR clinical instruments would detect oxygen-dependent cerebral cyt aa3 redox changes only when O2 delivery is extremely compromised. |
| | |
Authors:
|
M Ferrari; M A Williams; D A Wilson; N V Thakor; R J Traystman; D F Hanley |
Related Documents
:
|
565765 - Measurement of blood o2 and co2 concentrations using po2 and pco2 electrodes. 6736865 - Oxygen consumption and luminescence of porichthys photophores stimulated by potassium c... 2028105 - Diffusion and perfusion limitation in alveolar o2 exchange: shape of the blood o2 equil... 2010375 - Hepatic oxygen and lactate extraction during stagnant hypoxia. 8829345 - Immunomodulative effects of aflatoxins and selenium on human peripheral blood lymphocytes. 12657975 - Mesenteric hemodynamic response to circulatory shock. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The American journal of physiology Volume: 269 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1995 Aug |
Date Detail:
|
Created Date: 1995-09-22 Completed Date: 1995-09-22 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: H417-24 Citation Subset: IM |
Affiliation:
|
Department of Anesthesiology/Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anoxia / metabolism*, physiopathology Brain / enzymology*, physiopathology Cats Cerebrovascular Circulation Electron Transport Complex IV / metabolism* Evoked Potentials, Somatosensory Exchange Transfusion, Whole Blood* Feasibility Studies Female Fluorocarbons* Oxidation-Reduction Spectrophotometry, Infrared |
| Grant Support | |
ID/Acronym/Agency:
|
2-R01-NS-24282-03A2/NS/NINDS NIH HHS; 5-P01-NS-20020/NS/NINDS NIH HHS; R43-NS-27795-01/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Fluorocarbons; EC 1.9.3.1/Electron Transport Complex IV |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Structural changes and in situ aortic pressure-diameter relationship in long-term chemical-sympathec...
Next Document: Central angiotensin II AT1-receptor antagonism in normal and heart-failed sheep.