| Cat allergen level: its determinants and relationship to specific IgE to cat across European centers. | |
| | |
MedLine Citation:
|
PMID: 16950287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Cat allergen level in settled house dust and its determinants in Europe are unknown. OBJECTIVE: The aim of this study is to quantify the level of cat allergens in mattress dust, to study its determinants, and to analyze the relationship with cat specific IgE on community level across European centers. METHODS: Trained field workers collected dust from approximately 3000 mattresses during home visits in 22 European Community Respiratory Health Survey II centers. Sieved dust extracts were assayed for cat allergen using a mAb ELISA assay. RESULTS: The overall geometric mean cat allergen was 0.94 microg/g, ranging from 0.12 microg/g in Huelva, Spain, to 3.76 microg/g in Antwerp, Belgium. Current cat owners' homes showed substantially higher levels than past cat owners' and never cat owners' homes (geometric mean and 95% CI, 61.4 microg/g [48.4-77.9] vs 1.37 microg/g [0.97-1.9] vs 0.29 microg/g [0.27-0.31]). Community prevalence of cat ownership was moderately correlated with cat allergen levels in noncat owners (r(s) = 0.50), but not for past or current cat owners. The multilevel model identified community prevalence of cat keeping as the only statistically significant determinant of mattress cat allergen levels for noncat owners. However, averaged cat allergen levels per center were not related to community prevalence of detectable specific IgE to cat. CONCLUSION: Not having a cat in the home is associated with substantially lower Fel d 1 concentration, but does not protect against high Fel d 1 exposure in communities where cat ownership is common. CLINICAL IMPLICATIONS: People (including patients with cat allergy) who do not own cats may be exposed to high levels of cat allergen in their home, particularly if they live in communities with high levels of cat ownership. |
| | |
Authors:
|
Joachim Heinrich; Getahun Bero Bedada; Jan-Paul Zock; Susan Chinn; Dan Norbäck; Mario Olivieri; Cecilie Svanes; Michela Ponzio; Giuseppe Verlato; Simona Villani; Deborah Jarvis; Christina Luczynska; |
Related Documents
:
|
11307377 - Dimensional variability of nonstandardized greater taper finger spreaders with matching... 1427247 - Housing emergencies and the etiology of homelessness among the urban elderly. 16171937 - Coastal resource complexes of south india: options for sustainable management. 12964707 - Japan's anti-nuclear weapons policy misses its target, even in the war on terrorism. 12570967 - Norms, social networks, and hiv-related risk behaviors among urban disadvantaged drug u... 21819847 - The development and application of a proxy measure of alcohol-related traffic crashes f... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Multicenter Study Date: 2006-07-24 |
Journal Detail:
|
Title: The Journal of allergy and clinical immunology Volume: 118 ISSN: 0091-6749 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 2006 Sep |
Date Detail:
|
Created Date: 2006-09-04 Completed Date: 2006-10-17 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: United States |
Other Details:
|
Languages: eng Pagination: 674-81 Citation Subset: AIM; IM |
Affiliation:
|
GSF, National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany. joachim.heinrich@gsf.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Allergens
/
immunology*,
metabolism Animals Animals, Domestic / immunology* Antibody Specificity* Beds Cats / immunology* Cross-Sectional Studies Dust / immunology Epitopes / immunology* Europe Glycoproteins / immunology*, metabolism Housing Humans Immunoglobulin E / blood* Questionnaires |
| Chemical | |
Reg. No./Substance:
|
0/Allergens; 0/Dust; 0/Epitopes; 0/Fel d 1 protein, Felis domesticus; 0/Glycoproteins; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prenatal initiation of endotoxin airway exposure prevents subsequent allergen-induced sensitization ...
Next Document: Distribution and determinants of house dust mite allergens in Europe: the European Community Respira...