| Castration reduces the effect of serotonin-1A receptor stimulation on prepulse inhibition in rats. | |
| | |
MedLine Citation:
|
PMID: 14674858 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study examined the interaction between hormones and serotonin-1A (5-HT1A) receptor modulation of prepulse inhibition (PPI) of the acoustic startle response. Male and female rats were gonadectomized; some castrated rats received testosterone- or estrogen-filled implants. Rats were randomly injected with saline or 0.02 or 0.50 mg/kg 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a selective 5-HT1A receptor agonist. All rats showed a dose-dependent disruption of PPI in response to 8-OH-DPAT. In untreated castrated rats, this disruption was significantly reduced (33% compared with 78% in sham-operated rats). Testosterone treatment reversed this reduction, but estrogen was less effective. Ovariectomized and sham-operated rats showed similar PPI in response to 8-OH-DPAT. These data suggest that the effect of 8-OH-DPAT on PPI in male rats depends on circulating hormone levels, particularly testosterone. |
| | |
Authors:
|
Andrea Gogos; Maarten van den Buuse |
Related Documents
:
|
15951008 - Mdma (ecstasy) effects in pubescent rats: males are more sensitive than females. 17279088 - The importance of baseline in identifying 8-oh-dpat-induced effects on prepulse inhibit... 16882018 - Context-dependent behavioural and neuronal sensitization in striatum to mdma (ecstasy) ... 1355968 - The effects of mdma and other methylenedioxy-substituted phenylalkylamines on the struc... 3179568 - Prolactin levels in male and female rats perinatally treated with bromopride. 16122838 - Effects of physiological and pharmacological stimuli on dopamine release in the rat glo... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Behavioral neuroscience Volume: 117 ISSN: 0735-7044 ISO Abbreviation: Behav. Neurosci. Publication Date: 2003 Dec |
Date Detail:
|
Created Date: 2003-12-29 Completed Date: 2004-03-01 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8302411 Medline TA: Behav Neurosci Country: United States |
Other Details:
|
Languages: eng Pagination: 1407-15 Citation Subset: IM |
Copyright Information:
|
(c) 2003 APA |
Affiliation:
|
Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, Parkville, Victoria, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
8-Hydroxy-2-(di-n-propylamino)tetralin
/
pharmacology Acoustic Stimulation Animals Castration Dose-Response Relationship, Drug Estradiol / physiology* Female Ion Channel Gating / drug effects, physiology Male Neural Inhibition / drug effects, physiology* Ovariectomy Random Allocation Rats Rats, Sprague-Dawley Receptor, Serotonin, 5-HT1A / drug effects, physiology* Serotonin Agonists / pharmacology Startle Reaction / drug effects, physiology* Testosterone / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Serotonin Agonists; 112692-38-3/Receptor, Serotonin, 5-HT1A; 50-28-2/Estradiol; 58-22-0/Testosterone; 78950-78-4/8-Hydroxy-2-(di-n-propylamino)tetralin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ovarian hormones and cognition in the aged female rat: I. Long-term, but not short-term, ovariectomy...
Next Document: Novel tastes elevate c-fos expression in the central amygdala and insular cortex: implication for ta...