Document Detail

Castleman's disease and lymphoma: report of eight cases in HIV-negative patients and literature review.
MedLine Citation:
PMID:  11835348     Owner:  NLM     Status:  MEDLINE    
Castleman's disease (CD) is a rare atypical lymphoproliferative disorder associated with a risk of developing malignant lymphoma. We have recorded 8 HIV-negative patients presenting this association, 6 with non-Hodgkin's lymphoma (NHL) and 2 with Hodgkin's disease (HD). After literature review, we analyzed all reported cases of association CD-NHL (n = 23) and CD-HD (n = 27). NHL is more often associated with multicentric CD, its diagnosis being concurrent with CD diagnosis or occurring within 2 years. B-NHL is predominant (71%), and mantle cell lymphoma represents 40% of these B-NHL cases. NHL displays an aggressive course and is liable for death, especially in multicentric CD. HD occurs in localized CD of plasma cell type, usually in the same areas, is more often of interfollicular subtype, and its clinical course seems better than NHL. The association of CD and lymphoma seems to be more than coincidental, and its pathogenesis is discussed.
Claire Larroche; Patrice Cacoub; Jean Soulier; Eric Oksenhendler; Jean-Pierre Clauvel; Jean-Charles Piette; Martine Raphael
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  American journal of hematology     Volume:  69     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-08     Completed Date:  2002-02-21     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  119-26     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Wiley-Liss, Inc.
Department of Internal Medicine and Laboratory of Hematology, Hôpital Avicenne, Bobigny, France.
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MeSH Terms
Aged, 80 and over
Giant Lymph Node Hyperplasia / complications*,  pathology
HIV Seronegativity*
Hodgkin Disease / complications,  pathology
Lymphoma / complications*,  pathology
Lymphoma, Mantle-Cell / complications,  pathology
Lymphoma, Non-Hodgkin / complications,  pathology
Middle Aged

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