| Caspr2 antibodies in patients with thymomas. | |
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MedLine Citation:
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PMID: 20859119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myasthenia gravis is the best known autoimmune disease associated with thymomas, but other conditions can be found in patients with thymic tumors, including some that affect the central nervous system (CNS). We have become particularly interested in patients who have acquired neuromyotonia, the rare Morvan disease, or limbic encephalitis. Neuromyotonia mainly involves the peripheral nerves, Morvan disease affects both the peripheral nervous system and CNS, and limbic encephalitis is specific to the CNS. Many of these patients have voltage-gated potassium channel autoantibodies. All three conditions can be associated with thymomas and may respond to surgical removal of the underlying tumor together with immunotherapies and symptomatic treatments. Herein, we review the results of our recent studies that show that voltage-gated potassium channel autoantibodies are not principally directed against the potassium channels themselves but in some patients are directed against a protein that is complexed with potassium channels in both the peripheral nervous system and CNS, contactin-2 associated protein (Caspr2). These antibodies are common in the subgroup of patients with thymic malignancies. |
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Authors:
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Angela Vincent; Sarosh R Irani |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer Volume: 5 ISSN: 1556-1380 ISO Abbreviation: J Thorac Oncol Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-22 Completed Date: 2011-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101274235 Medline TA: J Thorac Oncol Country: United States |
Other Details:
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Languages: eng Pagination: S277-80 Citation Subset: IM |
Affiliation:
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Department of Clinical Neurology, John Radcliffe Hospital, Oxford, United Kingdom. angela.vincent@imm.ox.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autoantibodies
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immunology* Humans Membrane Proteins / immunology* Nerve Tissue Proteins / immunology* Potassium Channels / metabolism Thymoma / immunology*, pathology Thymus Neoplasms / immunology*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/CNTNAP2 protein, human; 0/Membrane Proteins; 0/Nerve Tissue Proteins; 0/Potassium Channels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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