| Caspofungin for the treatment of fungal infections: a systematic review of randomized controlled trials. | |
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MedLine Citation:
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PMID: 17207609 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During the last decade, owing to the low effectiveness and high toxicity of older antifungals, new antifungal agents have been released to the market for the treatment of patients with fungal infections. Several randomized controlled trials (RCTs) have been designed to evaluate the effectiveness of caspofungin in comparison with other antifungal agents. This review was conducted to examine further the role of caspofungin in the treatment of patients with fungal, mainly Candida, infections. Two reviewers independently performed the literature search, study selection and data extraction from relevant RCTs. A total of six RCTs comparing caspofungin with amphotericin B (deoxycholate in four and liposomal in one RCT) or fluconazole (in one RCT), which studied a total of 1974 patients, were included in our review. Success of the applied treatment in the clinically evaluable patients was achieved in 496/943 (52.6%) of the caspofungin-treated patients and in 381/852 (44.7%) of the amphotericin B- and lipid amphotericin B-treated patients. Discontinuation due to drug toxicity was significantly less common in patients receiving caspofungin than amphotericin B (odds ratio (OR) 0.25, 95% confidence interval (CI) 0.07-0.85, random effects model). Development of nephrotoxicity, hypokalaemia and fever also occurred significantly less often with caspofungin than amphotericin B (OR 0.23, 95% CI 0.14-0.36, fixed effects model; OR 0.3, 95% CI 0.12-0.76, random effects model; and OR 0.26, 95% CI 0.08-0.79, random effects model, respectively). No difference in mortality was noted. Caspofungin was associated with better clinical outcomes (higher cure and fewer adverse effects) than amphotericin B in the treatment of patients with fungal infections. |
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Authors:
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Matthew E Falagas; Fotinie Ntziora; Gregoria I Betsi; George Samonis |
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Publication Detail:
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Type: Journal Article; Review Date: 2007-01-04 |
Journal Detail:
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Title: International journal of antimicrobial agents Volume: 29 ISSN: 0924-8579 ISO Abbreviation: Int. J. Antimicrob. Agents Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-01-15 Completed Date: 2007-03-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9111860 Medline TA: Int J Antimicrob Agents Country: Netherlands |
Other Details:
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Languages: eng Pagination: 136-43 Citation Subset: IM |
Affiliation:
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Alfa Institute of Biomedical Sciences, 9 Neapoleos Street, 151 23 Marousi, Athens, Greece. m.falagas@aibs.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antifungal Agents
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therapeutic use* Echinocandins Humans Mycoses / drug therapy*, mortality Peptides, Cyclic / adverse effects, therapeutic use* Randomized Controlled Trials as Topic |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Echinocandins; 0/Peptides, Cyclic; 0/caspofungin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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