| Caspofungin primes the immune response of the larvae of Galleria mellonella and induces a non-specific antimicrobial response. | |
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MedLine Citation:
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PMID: 20947665 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The echinocandins (e.g. caspofungin) function by inhibiting the synthesis of 1,3-β-glucan in the fungal cell wall. While the potent antifungal activity of caspofungin has been well characterized in mammals, this study investigated the in vivo antifungal effect of caspofungin using larvae of the insect Galleria mellonella. Caspofungin was successful in increasing the survival of larvae that were inoculated with Candida albicans 1 h before the drug was administered, particularly when a concentration of 0.19 μg ml(-1) was used. Pre-injecting larvae with caspofungin also increased their survival when they were inoculated with either Staphylococcus aureus or C. albicans. Caspofungin administration resulted in an increase in the number of circulating immune cells (haemocytes), an increase in the expression of the genes encoding IMPI and transferrin, and an increase in the expression of a number of proteins (identified by liquid chromatography-mass spectrometry) some of which have immune functions. This work indicates that administration of caspofungin can increase the survival of infected G. mellonella larvae, and this is due to the antifungal properties of caspofungin and also to the ability of caspofungin to prime the insect's immune response. |
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Authors:
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Judy Kelly; Kevin Kavanagh |
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Publication Detail:
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Type: Journal Article Date: 2010-10-14 |
Journal Detail:
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Title: Journal of medical microbiology Volume: 60 ISSN: 1473-5644 ISO Abbreviation: J. Med. Microbiol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0224131 Medline TA: J Med Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 189-96 Citation Subset: IM |
Affiliation:
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Medical Mycology Unit, Department of Biology, National Institute for Cellular Biotechnology, NUI Maynooth, County Kildare, Ireland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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