| Caspase-7: a protease involved in apoptosis and inflammation. | |
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MedLine Citation:
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PMID: 19782763 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Caspase-7 was considered to be redundant with caspase-3 because these related cysteine proteases share an optimal peptide recognition sequence and have several endogenous protein substrates in common. In addition, both caspases are proteolytically activated by the initiator caspase-8 and -9 during death receptor- and DNA-damage-induced apoptosis, respectively. However, a growing body of biochemical and physiological data indicate that caspase-7 also differs in significant ways from caspase-3. For instance, several substrates are specifically cleaved by caspase-7, but not caspase-3. Moreover, caspase-7 activation requires caspase-1 inflammasomes under inflammatory conditions, while caspase-3 processing proceeds independently of caspase-1. Finally, caspase-7 deficient mice are resistant to endotoxemia, whereas caspase-3 knockout mice are susceptible. These findings suggest that specifically interfering with caspase-7 activation may hold therapeutic value for the treatment of cancer and inflammatory ailments. |
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Authors:
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Mohamed Lamkanfi; Thirumala-Devi Kanneganti |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2009-09-25 |
Journal Detail:
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Title: The international journal of biochemistry & cell biology Volume: 42 ISSN: 1878-5875 ISO Abbreviation: Int. J. Biochem. Cell Biol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-11-30 Completed Date: 2010-02-25 Revised Date: 2012-04-09 |
Medline Journal Info:
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Nlm Unique ID: 9508482 Medline TA: Int J Biochem Cell Biol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 21-4 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Ghent University, B-9000 Ghent, Belgium; Department of Medical Protein Research, VIB, B-9000 Ghent, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis* Caspase 7 / chemistry, metabolism* Humans Inflammation / enzymology*, pathology*, therapy |
| Grant Support | |
ID/Acronym/Agency:
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AR056296/AR/NIAMS NIH HHS; R01 AR056296-01A1/AR/NIAMS NIH HHS; R01 AR056296-02/AR/NIAMS NIH HHS; R01 AR056296-02S2/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 3.4.22.-/Caspase 7 |
| Comments/Corrections | |
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