| Casein protein results in higher prandial and exercise induced whole body protein anabolism than whey protein in chronic obstructive pulmonary disease. | |
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MedLine Citation:
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PMID: 22512824 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exercise is known to improve physical functioning and health status in Chronic Obstructive Pulmonary Disease (COPD). Recently, disturbances in protein turnover and amino acid kinetics have been observed after exercise in COPD. The objective was to investigate which dairy protein is able to positively influence the protein metabolic response to exercise in COPD. 8 COPD patients and 8 healthy subjects performed a cycle test on two days while ingesting casein or whey protein. Whole body protein breakdown (WbPB), synthesis (WbPS), splanchnic amino acid extraction (SPE), and NetWbPS (=WbPS-WbPB) were measured using stable isotope methodology during 20 min of exercise (at 50% peak work load of COPD group). The controls performed a second exercise test at the same relative workload. Exercise was followed by 1 h of recovery. In the healthy group, WbPS, SPE, and NetPS were higher during casein than during whey feeding (P<.01). WbPS and NetPS were higher during exercise, independent of exercise intensity (P<.01). NetPS was higher during casein feeding in COPD due to lower WbPB (P<.05). Higher SPE was found during exercise during casein and whey feeding in COPD (P<.05). Lactate levels during exercise were higher in COPD (P<.05) independent of the protein. Post-exercise, lower NetPS values were found independent of protein type in both groups. Casein resulted in more protein anabolism than whey protein which was maintained during and following exercise in COPD. Optimizing protein intake might be of importance for muscle maintenance during daily physical activities in COPD. |
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Authors:
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Mariëlle P K J Engelen; Erica P A Rutten; Carmen L N De Castro; Emiel F M Wouters; Annemie M W J Schols; Nicolaas E P Deutz |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-04-17 |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 61 ISSN: 1532-8600 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-08-27 Completed Date: 2012-10-26 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
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Languages: eng Pagination: 1289-300 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Center for Translational Research in Aging & Longevity, Donald W. Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, USA. mpkj.engelen@ctral.org |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT01418469 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Aged Amino Acids / metabolism Bicycling Case-Control Studies Caseins / administration & dosage*, chemistry, metabolism* Eating Exercise* / physiology Exercise Test Humans Male Middle Aged Milk Proteins / administration & dosage*, chemistry, metabolism* Protein Biosynthesis Proteolysis* Pulmonary Disease, Chronic Obstructive / drug therapy, metabolism* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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R-01HL095903/HL/NHLBI NIH HHS; R01 HL095903-01A1/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Caseins; 0/Milk Proteins; 0/whey protein |
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