| Casein hydrolysate formula-induced liver dysfunction in a neonate with non-immunoglobulin E-mediated cow's milk allergy. | |
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MedLine Citation:
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PMID: 18361106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 10-day-old male neonate was admitted with bilious vomiting and gross hematochezia. Peripheral eosinophilia, delayed positive skin prick test to artificial milk, and elevated eosinophil cationic protein levels suggested cow's milk allergy. Fluid infusion with prohibition of oral intake improved the digestive symptoms. Breast-feeding was resumed on hospital day 3 and only casein hydrolysate formula was fed from day 7 onward. Nevertheless, eosinophilia and elevated transaminase levels developed on day 14. Liver dysfunction associated with casein hydrolysate formula was suspected and the infant was transferred to soy formula. Eosinophil counts decreased and transaminase levels were normalized on day 19. A cow's milk protein-specific lymphocyte proliferation test was positive for alpha-casein, beta-lactoglobulin, and bovine serum albumin, indicating sensitization of T cells to cow's milk proteins. These observations suggest that careful attention should be paid to liver dysfunction in non-immunoglobulin E-mediated cow's milk allergy, even when hypoallergenic formula is used. |
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Authors:
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K Yada; K Yoshida; Y Sakurai; M Kimura; H Yasuhara; I Tanaka; A Yoshioka |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología Volume: 18 ISSN: 1018-9068 ISO Abbreviation: J Investig Allergol Clin Immunol Publication Date: 2008 |
Date Detail:
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Created Date: 2008-03-25 Completed Date: 2008-05-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107858 Medline TA: J Investig Allergol Clin Immunol Country: Spain |
Other Details:
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Languages: eng Pagination: 67-70 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Nara Medical University School of Medicine, Kashihara, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Caseins
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adverse effects Eosinophilia / etiology Humans Immunoglobulin E / blood Infant Formula* Infant, Newborn Liver Diseases / etiology* Male Milk Hypersensitivity / complications* |
| Chemical | |
Reg. No./Substance:
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0/Caseins; 37341-29-0/Immunoglobulin E; 65072-00-6/casein hydrolysate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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