Document Detail

Casein hydrolysate formula-induced liver dysfunction in a neonate with non-immunoglobulin E-mediated cow's milk allergy.
MedLine Citation:
PMID:  18361106     Owner:  NLM     Status:  MEDLINE    
A 10-day-old male neonate was admitted with bilious vomiting and gross hematochezia. Peripheral eosinophilia, delayed positive skin prick test to artificial milk, and elevated eosinophil cationic protein levels suggested cow's milk allergy. Fluid infusion with prohibition of oral intake improved the digestive symptoms. Breast-feeding was resumed on hospital day 3 and only casein hydrolysate formula was fed from day 7 onward. Nevertheless, eosinophilia and elevated transaminase levels developed on day 14. Liver dysfunction associated with casein hydrolysate formula was suspected and the infant was transferred to soy formula. Eosinophil counts decreased and transaminase levels were normalized on day 19. A cow's milk protein-specific lymphocyte proliferation test was positive for alpha-casein, beta-lactoglobulin, and bovine serum albumin, indicating sensitization of T cells to cow's milk proteins. These observations suggest that careful attention should be paid to liver dysfunction in non-immunoglobulin E-mediated cow's milk allergy, even when hypoallergenic formula is used.
K Yada; K Yoshida; Y Sakurai; M Kimura; H Yasuhara; I Tanaka; A Yoshioka
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of investigational allergology & clinical immunology     Volume:  18     ISSN:  1018-9068     ISO Abbreviation:  J Investig Allergol Clin Immunol     Publication Date:  2008  
Date Detail:
Created Date:  2008-03-25     Completed Date:  2008-05-06     Revised Date:  2013-07-31    
Medline Journal Info:
Nlm Unique ID:  9107858     Medline TA:  J Investig Allergol Clin Immunol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  67-70     Citation Subset:  IM    
Department of Pediatrics, Nara Medical University School of Medicine, Kashihara, Japan.
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MeSH Terms
Caseins / adverse effects
Eosinophilia / etiology
Immunoglobulin E / blood
Infant Formula*
Infant, Newborn
Liver Diseases / etiology*
Milk Hypersensitivity / complications*
Reg. No./Substance:
0/Caseins; 37341-29-0/Immunoglobulin E; 65072-00-6/casein hydrolysate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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