Document Detail

Casein hydrolysate containing Val-Pro-Pro and Ile-Pro-Pro improves central blood pressure and arterial stiffness in hypertensive subjects: A randomized, double-blind, placebo-controlled trial.
MedLine Citation:
PMID:  21723554     Owner:  NLM     Status:  Publisher    
OBJECTIVE: This trial evaluated the effects of casein hydrolysate containing milk-derived peptides, Val-Pro-Pro (VPP) and Ile-Pro-Pro (IPP), on central blood pressure and arterial stiffness. METHODS: A randomized, double-blind, placebo-controlled trial was conducted in 70 Japanese subjects aged 50-69 years with untreated stage-I hypertension. They were randomly assigned to two groups, which received either placebo tablets or active tablets containing 3.4mg of VPP and IPP. At the beginning and end of the 8-week intervention, hemodynamic parameters, including central blood pressure and brachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness, were measured. RESULTS: A significant difference in changes in central systolic blood pressure between the groups was observed (active: -11.0±11.0 vs placebo: -4.5±9.6mmHg, P<0.01). In the active group, reductions in baPWV (-73.9±130.0 vs -8.4±137.1cm/s, P<0.05), brachial SBP (-10.5±11.5 vs -3.9±9.6mmHg, P<0.05), and radial mean blood pressure (-7.3±8.9 vs -2.0±7.4mmHg, P<0.01) were significantly greater as compared with the placebo group. CONCLUSION: Casein hydrolysate containing VPP and IPP improves central SBP and baPWV in hypertensive subjects, which suggests VPP and IPP might have beneficial effects on arterial properties.
Teppei Nakamura; Jun Mizutani; Kohji Ohki; Kazuhisa Yamada; Naoyuki Yamamoto; Masahiko Takeshi; Kenji Takazawa
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-13
Journal Detail:
Title:  Atherosclerosis     Volume:  -     ISSN:  1879-1484     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-7-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
R&D Center, Calpis Co., Ltd., 5-11-10 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-0206, Japan.
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