| Case summary: Benjamin. | |
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MedLine Citation:
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PMID: 7894847 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Benjamin was diagnosed with Aspberger's syndrome on starting school. Prior to that, at the age of five years he presented with seizures involving deviation of the head and eyes to the right and jerking of the limbs. EEG was very abnormal with multifocal paroxysmal activity and occasional bursts of spike and slow wave activity. CT scan and MRI were normal and investigations failed to identify any underlying aetiology for the seizures. Carbamazepine was initially successful in controlling the seizures but improvement was not sustained despite maximal tolerated doses. A similar course of events was seen with sodium valproate, initially in combination with ethosuximide (for emergent tonic-clonic and absence seizures), then with vigabatrin (which unmasked myoclonic seizures), clonazepam and finally lamotrigine. The EEG remained abnormal even during periods of improved seizure control and there was no improvement in his Aspberger's syndrome. His epilepsy syndrome has not been classified. Subsequent treatment options include lamotrigine monotherapy. |
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Authors:
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C D Rittey |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Seizure : the journal of the British Epilepsy Association Volume: 3 Suppl A ISSN: 1059-1311 ISO Abbreviation: Seizure Publication Date: 1994 Dec |
Date Detail:
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Created Date: 1995-04-27 Completed Date: 1995-04-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9306979 Medline TA: Seizure Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 25-7 Citation Subset: IM |
Affiliation:
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Children's Hospital, Sheffield, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticonvulsants
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adverse effects,
therapeutic use* Autistic Disorder / classification, drug therapy, etiology Child, Preschool Diagnosis, Differential Diagnostic Imaging Drug Therapy, Combination Electroencephalography / drug effects Epilepsies, Myoclonic / classification, drug therapy, etiology Epilepsy / classification, drug therapy*, etiology Epilepsy, Absence / classification, drug therapy, etiology Epilepsy, Tonic-Clonic / classification, drug therapy, etiology Evoked Potentials / drug effects Humans Male |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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