Document Detail


Case studies of the synthesis of bioactive cyclodepsipeptide natural products.
MedLine Citation:
PMID:  23348990     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Cyclodepsipeptide natural products often display intriguing biological activities that along with their complex molecular scaffolds, makes them interesting targets for chemical synthesis. Although cyclodepsipeptides feature highly diverse chemical structures, their synthesis is often associated with similar synthetic challenges such as the establishment of a suitable macrocyclization methodology. This review therefore compiles case studies of synthetic approaches to different bioactive cyclodepsipeptide natural products, thereby illustrating obstacles of cyclodepsipeptide synthesis as well as their overcomings.
Authors:
Sara C Stolze; Markus Kaiser
Publication Detail:
Type:  Journal Article     Date:  2013-01-24
Journal Detail:
Title:  Molecules (Basel, Switzerland)     Volume:  18     ISSN:  1420-3049     ISO Abbreviation:  Molecules     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100964009     Medline TA:  Molecules     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1337-67     Citation Subset:  IM    
Affiliation:
Zentrum für Medizinische Biotechnologie, Fakultät für Biologie, Universitätsstraße 2, 45117 Essen, Germany. markus.kaiser@uni-due.de.
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