| Case series of pediatric acute leukemia without a peripheral blood abnormality, detected by magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 21509438 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Although abnormal peripheral blood counts are a key diagnostic finding for acute leukemia in children, between 2003 and 2010 we observed seven pediatric cases without peripheral blood abnormalities and showing abnormal signals in the bone marrow by magnetic resonance imaging (MRI). The common chief complaint in these patients was bone pain and fever. Bone marrow tests revealed six out of the seven cases to be acute leukemia, whereas one patient was diagnosed with juvenile idiopathic arthritis (JIA). There was no evident difference in MRI findings between leukemia patients and JIA patient. In three cases of leukemia, initial bone marrow aspiration failed to show the presence of leukemic cells, and diagnosis was only made by repeated bone marrow examination. Our findings indicate that in some cases MRI detects leukemia at an earlier phase than does bone marrow aspiration, suggesting that MRI is useful for the diagnosis of acute leukemia. |
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Authors:
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Motohiro Kato; Katsuyoshi Koh; Akira Kikuchi; Daisuke Toyama; Shinji Mochizuki; Naoki Uchisaka; Yoshihisa Nagatoshi; Risa Tanaka; Tsutomu Oh-Ishi; Kumiko Nozawa; Eiji Oguma; Ryoji Hanada |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-21 |
Journal Detail:
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Title: International journal of hematology Volume: - ISSN: 1865-3774 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111627 Medline TA: Int J Hematol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Hematology/Oncology, Saitama Children's Medical Center, 2100 Magome, Iwatsuki-ku, Saitama, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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