| Case report: splenomegaly and splenic sequestration in an adult with sickle cell anemia. | |
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MedLine Citation:
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PMID: 8969620 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Splenomegaly in adult patients with homozygous sickle cell anemia (HbSS) is uncommon and splenic sequestration crises are rare. This paper describes a patient with HbSS who, at the age of 24, began to experience acute splenic sequestration crises. These episodes occurred with sufficient frequency and severity to warrant splenectomy. This case is presented to emphasize that, although rare, splenomegaly can persist in adults with homozygous HbSS and can be associated with severe and even life-threatening splenic sequestration. The incidence of splenomegaly in adults with HbSS and the factors linked to it will be discussed and the published reports of splenic sequestration crises in this patient population reviewed. It appears that high hemoglobin F (HbF) levels and alpha-thalassemia may be important etiologic factors in causing persistence of splenomegaly and predisposing patients to splenic sequestration crises. |
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Authors:
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S Moll; E P Orringer |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of the medical sciences Volume: 312 ISSN: 0002-9629 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 1996 Dec |
Date Detail:
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Created Date: 1997-01-15 Completed Date: 1997-01-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 299-302 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anemia, Sickle Cell / complications, metabolism* Fetal Hemoglobin / genetics, metabolism Hemoglobins / metabolism Homozygote Humans Male Radiography Splenectomy Splenomegaly / metabolism* Technetium Tc 99m Sulfur Colloid / diagnostic use |
| Grant Support | |
ID/Acronym/Agency:
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HL28391/HL/NHLBI NIH HHS; RR00046/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/Technetium Tc 99m Sulfur Colloid; 9034-63-3/Fetal Hemoglobin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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