Document Detail


Case report: pentamidine and polymorphic ventricular tachycardia revisited.
MedLine Citation:
PMID:  8475949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pentamidine isethionate has been associated with ventricular tachyarrhythmias, including torsade de pointes. This article reports two cases of this complication and reviews all reported cases to date. Pentamidine-induced torsade de pointes may be related to serum magnesium levels and hypomagnesemia may synergistically induce torsade. Torsade de pointes occurred after an average of 10 days of treatment with pentamidine. In these patients, no other acute side effects of pentamidine were observed. Torsade de pointes can be treated when recognized early, possibly without discontinuation of pentamidine. When QTc interval prolongation is observed, early magnesium supplementation is advocated.
Authors:
S Mani; A G Kocheril; V T Andriole
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  305     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-05-20     Completed Date:  1993-05-20     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  236-40     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510.
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MeSH Terms
Descriptor/Qualifier:
Adult
Humans
Male
Pentamidine / adverse effects*
Pneumonia, Pneumocystis / drug therapy
Torsades de Pointes / chemically induced*
Chemical
Reg. No./Substance:
100-33-4/Pentamidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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