Document Detail

Case report: oxaprozin and fatal toxic epidermal necrolysis.
MedLine Citation:
PMID:  9710730     Owner:  NLM     Status:  MEDLINE    
We have presented a case of fulminating TEN with a fatal outcome. We believe there is strong probability that the TEN was caused by a propionic acid NSAID oxaprozin. This is the first reported case of TEN related to this particular agent. Toxic epidermal necrolysis has been reported with all types of NSAIDs. It appears from this case that switching from one class of nonsteroidal anti-inflammatories to another is not always without risk. Despite the class of nonsteroidal anti-inflammatory agent used, the possibility of systemic reaction cannot be excluded.
C N Paul; D W Voigt; K E Clyne; S L Hansen
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of burn care & rehabilitation     Volume:  19     ISSN:  0273-8481     ISO Abbreviation:  J Burn Care Rehabil     Publication Date:    1998 Jul-Aug
Date Detail:
Created Date:  1998-10-19     Completed Date:  1998-10-19     Revised Date:  2006-08-15    
Medline Journal Info:
Nlm Unique ID:  8110188     Medline TA:  J Burn Care Rehabil     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  321-3     Citation Subset:  IM    
Burn and Wound Center, Saint Elizabeth Community Health Center, Lincoln, Nebraska 68510, USA.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
Epidermal Necrolysis, Toxic / etiology*
Fatal Outcome
Propionic Acids / adverse effects*
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Propionic Acids; 21256-18-8/oxaprozin

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