Document Detail


Case report: multisystem failure following intravenous iopamidol.
MedLine Citation:
PMID:  1395388     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A case of life-threatening adverse effects following intravenous administration of a non-ionic contrast medium is reported. The patient, a 68-year-old diabetic hypertensive male with dyspnoea and cough had an abnormal chest radiograph, revealing congestive heart failure and an enlarged right hilum. Computed tomography (CT) of the chest was performed using 100 cm3 of intravenous iopamidol. Within half an hour the patient developed abdominal cramping, vomiting, and diarrhoea, followed by hypotension, tachycardia, fever to 40 degrees C, and delirium. His course was complicated by disseminated intravascular coagulation, rhabdomyolysis, renal failure, respiratory arrest, and atrial fibrillation. There was no evidence of infection, neoplastic disease, or myocardial infarction. Over the next month the patient slowly recovered. One other case report implicates a contrast agent with a similar syndrome. The features of this case fulfil the criteria for a probable adverse drug reaction of a type and severity rarely encountered.
Authors:
L M Lucas; C A Colley; G H Gordon
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical radiology     Volume:  45     ISSN:  0009-9260     ISO Abbreviation:  Clin Radiol     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-10-29     Completed Date:  1992-10-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1306016     Medline TA:  Clin Radiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  276-7     Citation Subset:  IM    
Affiliation:
Medical Service, Veterans Affairs Medical Center, Portland, OR 97207.
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MeSH Terms
Descriptor/Qualifier:
Aged
Humans
Injections, Intravenous
Iopamidol / administration & dosage,  adverse effects*
Male
Multiple Organ Failure / chemically induced*
Radiography, Thoracic
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
62883-00-5/Iopamidol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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