Document Detail

Case report: the lupus anticoagulant-hypoprothrombinemia syndrome.
MedLine Citation:
PMID:  8172228     Owner:  NLM     Status:  MEDLINE    
The lupus anticoagulant is a well-described in vitro phenomenon that may be associated with arterial and venous thrombotic episodes. The lupus anticoagulant is never accompanied by a hemorrhagic diathesis unless it is associated with a second coagulation abnormality such as thrombocytopenia or hypoprothrombinemia. The lupus anticoagulant-hypoprothrombinemia syndrome is now a well-defined entity that may cause a severe, life-threatening hemorrhagic diathesis. The hypoprothrombinemia in this syndrome is the result of rapid clearance of prothrombin-antiprothrombin antibody complexes by the reticulo-endothelial system. The cause of antiprothrombin antibody formation is unknown. The authors describe a recent experience with a patient with this syndrome who initially had recurrent, life-threatening gastrointestinal bleeding. They were able to demonstrate hypoprothrombinemia and the presence of prothrombin-antiprothrombin antibody immune complexes. The patient was treated with prednisone, with correction of the bleeding disorder; however, the patient had resultant death from thrombosis. A literature review of the past 30 years as it relates to the discovery and treatment of this phenomenon is included.
N W Peacock; S P Levine
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  307     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-06-02     Completed Date:  1994-06-02     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  346-9     Citation Subset:  AIM; IM    
Cancer Therapy and Research Center, San Antonio, Texas 78229.
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MeSH Terms
Antithrombins / metabolism
Blood Coagulation Factors / analysis
Gastrointestinal Hemorrhage / blood*,  therapy
Lupus Coagulation Inhibitor / analysis*
Partial Thromboplastin Time
Prednisone / therapeutic use
Prothrombin / analysis*,  metabolism
Prothrombin Time
Reg. No./Substance:
0/Antithrombins; 0/Blood Coagulation Factors; 0/Lupus Coagulation Inhibitor; 53-03-2/Prednisone; 9001-26-7/Prothrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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