| Case report and brief review: IL-2-induced myocarditis. | |
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MedLine Citation:
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PMID: 15493361 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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High dose bolus interleukin 2 (IL-2) used in the treatment of metastatic melanoma and renal cell carcinoma is known to have the potential for serious cardiac toxicity. At our institution 2 of 57 (3.5%) patients developed IL-2 induced myocarditis. The constellation of electrocardiographic changes and elevated troponin I is the hallmark of myocarditis. In this setting of high dose IL-2 therapy it is important to keep myocarditis in the differential in addition to the more frequently sought diagnosis of acute myocardial infarction. Although the gold standard for diagnosis is endomyocardial biopsy, there is considerable false negative rate. It may be reasonable to make the diagnosis on clinical grounds, while providing supportive care. Future investigation is required to better understand the pathophysiology and what factors may influence expression of this toxicity. |
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Authors:
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Robert M Eisner; Aliya Husain; Joseph I Clark |
Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Cancer investigation Volume: 22 ISSN: 0735-7907 ISO Abbreviation: Cancer Invest. Publication Date: 2004 |
Date Detail:
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Created Date: 2004-10-20 Completed Date: 2004-11-04 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8307154 Medline TA: Cancer Invest Country: United States |
Other Details:
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Languages: eng Pagination: 401-4 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Loyola University Medical Center, Maywood, Illinois 60153, USA. reisner@lumc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Renal Cell
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drug therapy,
secondary Fatal Outcome Female Heart Aneurysm / etiology Heart Diseases / etiology Humans Interleukin-2 / administration & dosage, adverse effects*, therapeutic use Kidney Neoplasms / drug therapy, pathology Male Melanoma / drug therapy, secondary Middle Aged Myocarditis / chemically induced*, complications, pathology Myocardium / pathology Retrospective Studies Tachycardia, Supraventricular / etiology Thrombosis / etiology |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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