Document Detail

Case report and brief review: IL-2-induced myocarditis.
MedLine Citation:
PMID:  15493361     Owner:  NLM     Status:  MEDLINE    
High dose bolus interleukin 2 (IL-2) used in the treatment of metastatic melanoma and renal cell carcinoma is known to have the potential for serious cardiac toxicity. At our institution 2 of 57 (3.5%) patients developed IL-2 induced myocarditis. The constellation of electrocardiographic changes and elevated troponin I is the hallmark of myocarditis. In this setting of high dose IL-2 therapy it is important to keep myocarditis in the differential in addition to the more frequently sought diagnosis of acute myocardial infarction. Although the gold standard for diagnosis is endomyocardial biopsy, there is considerable false negative rate. It may be reasonable to make the diagnosis on clinical grounds, while providing supportive care. Future investigation is required to better understand the pathophysiology and what factors may influence expression of this toxicity.
Robert M Eisner; Aliya Husain; Joseph I Clark
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Cancer investigation     Volume:  22     ISSN:  0735-7907     ISO Abbreviation:  Cancer Invest.     Publication Date:  2004  
Date Detail:
Created Date:  2004-10-20     Completed Date:  2004-11-04     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8307154     Medline TA:  Cancer Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  401-4     Citation Subset:  IM    
Department of Internal Medicine, Loyola University Medical Center, Maywood, Illinois 60153, USA.
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MeSH Terms
Carcinoma, Renal Cell / drug therapy,  secondary
Fatal Outcome
Heart Aneurysm / etiology
Heart Diseases / etiology
Interleukin-2 / administration & dosage,  adverse effects*,  therapeutic use
Kidney Neoplasms / drug therapy,  pathology
Melanoma / drug therapy,  secondary
Middle Aged
Myocarditis / chemically induced*,  complications,  pathology
Myocardium / pathology
Retrospective Studies
Tachycardia, Supraventricular / etiology
Thrombosis / etiology
Reg. No./Substance:

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