Document Detail

Case report: acute pancreatitis induced by Clozapine.
MedLine Citation:
PMID:  15832593     Owner:  NLM     Status:  MEDLINE    
Two percent of acute pancreatitis are drug induced. In the present paper, we reported the case of a 39 year-old patient with chronic-hallucinatory schizophrenia who developed symptomatic pancreatitis during the clozapine dose titration performed to reach the therapeutic range. Diagnosis of pancreatitis was suggested by clinical examination and abnormal laboratory values of pancreatic enzymes and confirmed by C-T scan and ultrasonography. The causal incrimination of clozapine in this case seems likely as all other possible causes of pancreatitis were excluded, as AP developed shortly after the introduction of the drug and as the pancreatic enzymes normalized after clozapine was stopped. No rechallenge to confirm the causal relationship was however attempted. So far, only eight cases of acute pancreatitis have been reported in association with clozapine use. Clozapine is an atypical antipsychotic drug which belongs to the chemical class of dibenzodiazepines. The mechanism by which clozapine could produce acute pancreatitis remained unclear. Nevertheless, we advocate a careful biological follow-up (measuring periodically the concentrations of amylase, lipase and triglycerides) during the treatment by clozapine.
J-M F Bayard; O S Descamps; S Evrard; J M Dumonceau; L Servais; Z Zingir; S Adams; V Dassy; E Stillemans; A Seutin; P Titeca; J Titeca
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Acta gastro-enterologica Belgica     Volume:  68     ISSN:  0001-5644     ISO Abbreviation:  Acta Gastroenterol. Belg.     Publication Date:    2005 Jan-Mar
Date Detail:
Created Date:  2005-04-18     Completed Date:  2005-05-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0414075     Medline TA:  Acta Gastroenterol Belg     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  92-4     Citation Subset:  IM    
Service de Psychiatrie, Centre hospitalier Jolimont-Lobbes, Haine Saint-Paul, Belgium.
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MeSH Terms
Acute Disease
Clozapine / adverse effects*,  therapeutic use
Dose-Response Relationship, Drug
Drug Administration Schedule
Follow-Up Studies
Long-Term Care
Pancreatic Function Tests
Pancreatitis / chemically induced*,  diagnosis,  therapy
Risk Assessment
Schizophrenia, Paranoid / diagnosis,  drug therapy*
Severity of Illness Index
Tomography, X-Ray Computed
Reg. No./Substance:

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