| Case report: acromegaly and Cushing's disease in a patient with synchronous pituitary adenomas. | |
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MedLine Citation:
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PMID: 1442869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 40-year-old white woman presented with hirsutism, amenorrhea, generalized fatigue, diffuse weight gain, acral changes, and coarsened facial features. Physical examination revealed mild diastolic hypertension, acromegalic features, hirsutism, and seborrhea. The growth hormone concentration was elevated and did not suppress after glucose administration. Urinary free cortisol excretion was increased and was not suppressed during a 2 mg low-dose dexamethasone suppression test. Magnetic resonance imaging of the sella demonstrated a 1.3 x 1.2 x 0.8 cm pituitary adenoma. Trans-sphenoidal resection was performed, and portions of the resected tumor were analyzed by routine pathologic methods. Histopathologic and immunohistochemical findings indicated discrete growth hormone- and adrenocorticotropic hormone-producing pituitary adenomas. Coexisting acromegaly and Cushing's syndrome due to pituitary neoplasia was previously reported in two patients. However, to the authors' knowledge, this represents the first description of a patient with acromegaly and Cushing's disease resulting from discrete synchronous adenomas of the pituitary gland as defined by modern histopathologic techniques. |
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Authors:
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L S Blevins; G S Hall; D H Madoff; E R Laws; G S Wand |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of the medical sciences Volume: 304 ISSN: 0002-9629 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 1992 Nov |
Date Detail:
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Created Date: 1992-12-04 Completed Date: 1992-12-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 294-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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17-Ketosteroids
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urine Acromegaly / blood, etiology*, urine Adenoma / blood, diagnosis*, surgery, urine Adult Cushing Syndrome / blood, etiology*, urine Dehydroepiandrosterone / analogs & derivatives, blood Dehydroepiandrosterone Sulfate Dexamethasone / diagnostic use Female Hirsutism / blood, etiology, urine Humans Hydrocortisone / urine Magnetic Resonance Imaging Pituitary Neoplasms / blood, diagnosis*, surgery, urine Reference Values Testosterone / blood |
| Grant Support | |
ID/Acronym/Agency:
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DK-01298/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/17-Ketosteroids; 50-02-2/Dexamethasone; 50-23-7/Hydrocortisone; 53-43-0/Dehydroepiandrosterone; 58-22-0/Testosterone; 651-48-9/Dehydroepiandrosterone Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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