Document Detail


Case report: Treatment failure using propanolol for treatment of focal subglottic hemangioma.
MedLine Citation:
PMID:  20846505     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Subglottic hemangioma is a rare, potentially life threatening tumor of infancy which poses serious treatment challenges. A number of medical and surgical therapies over the years have met with variable success, and are associated with numerous potential morbidities. A potential windfall in the management of infantile hemangiomas has arisen with the recent identification of propanolol as a highly efficacious and relatively safe new treatment modality. At least five reports in the literature have described the rapid, successful treatment of airway hemangiomas with oral propanolol. We describe the first reported treatment failure with propanolol for subglottic hemangioma in an infant who initially responded dramatically to the medication.
Authors:
Karina T Canadas; Eric D Baum; Stella Lee; Samuel T Ostrower
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of pediatric otorhinolaryngology     Volume:  74     ISSN:  1872-8464     ISO Abbreviation:  Int. J. Pediatr. Otorhinolaryngol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-09     Completed Date:  2010-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003603     Medline TA:  Int J Pediatr Otorhinolaryngol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  956-8     Citation Subset:  IM    
Affiliation:
Department of Otolaryngology Head & Neck Surgery, Yale University School of Medicine, United States.
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MeSH Terms
Descriptor/Qualifier:
Female
Follow-Up Studies
Glottis / pathology
Hemangioma / congenital,  drug therapy*,  pathology,  surgery
Humans
Infant
Laryngeal Neoplasms / congenital,  drug therapy*,  pathology,  surgery
Laryngoscopy / methods
Laryngostenosis / diagnosis,  etiology
Neoplasm Recurrence, Local / pathology*,  surgery
Otorhinolaryngologic Surgical Procedures / methods*
Propranolol / administration & dosage*
Retreatment
Risk Assessment
Treatment Failure
Treatment Outcome
Chemical
Reg. No./Substance:
525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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