| Case report: Retinopathy after malaria prophylaxis with chloroquine. | |
| | |
MedLine Citation:
|
PMID: 11716127 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Chloroquine retinopathy (CR) is a major complication of long-term malaria prophylaxis (LTMP) causing permanent visual dysfunction and occasionally blindness. After an extensive review of the published accounts of CR, we concluded that the risk of retinopathy in subjects receiving LTMP is limited to a cumulative dose that does not exceed 140 g. We present a case of CR that occurred after 8 years of malaria prophylaxis with chloroquine at a cumulative dose of 125 g. Because a threshold dose of chloroquine for retinal toxicity has not been established, careful, ongoing screening is required, especially as the cumulative dose increases. |
| | |
Authors:
|
S Bertagnolio; E Tacconelli; G Camilli; M Tumbarello |
Related Documents
:
|
19528277 - Pharmacokinetics and ex vivo pharmacodynamic antimalarial activity of dihydroartemisini... 7283237 - Anthelmintic efficacy of albendazole in calves with naturally acquired fasciola hepatic... 6476577 - Efficacy of triclabendazole against fasciola hepatica and fascioloides magna in natural... 7660447 - Ivermectin treatment in severe asymmetric reactive onchodermatitis (sowda) in sudan. 15235157 - Dose-dependent effects of chronic iron burden on heart aldehyde and acyloin production ... 8404547 - Ten and ninety-day toxicity studies of 2-chlorophenol in sprague-dawley rats. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: The American journal of tropical medicine and hygiene Volume: 65 ISSN: 0002-9637 ISO Abbreviation: Am. J. Trop. Med. Hyg. Publication Date: 2001 Nov |
Date Detail:
|
Created Date: 2001-11-21 Completed Date: 2001-12-07 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0370507 Medline TA: Am J Trop Med Hyg Country: United States |
Other Details:
|
Languages: eng Pagination: 637-8 Citation Subset: AIM; IM |
Affiliation:
|
Department of Infectious Diseases, Catholic University, Rome, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antimalarials
/
adverse effects* Chloroquine / adverse effects* Female Humans Malaria / prevention & control* Middle Aged Retinal Diseases / chemically induced* |
| Chemical | |
Reg. No./Substance:
|
0/Antimalarials; 54-05-7/Chloroquine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Multiplicity of Plasmodium falciparum infection in pregnancy.
Next Document: Association of splenomegaly with cerebral malaria and decreased concentrations of reactive nitrogen ...