Document Detail

Case report: Retinopathy after malaria prophylaxis with chloroquine.
MedLine Citation:
PMID:  11716127     Owner:  NLM     Status:  MEDLINE    
Chloroquine retinopathy (CR) is a major complication of long-term malaria prophylaxis (LTMP) causing permanent visual dysfunction and occasionally blindness. After an extensive review of the published accounts of CR, we concluded that the risk of retinopathy in subjects receiving LTMP is limited to a cumulative dose that does not exceed 140 g. We present a case of CR that occurred after 8 years of malaria prophylaxis with chloroquine at a cumulative dose of 125 g. Because a threshold dose of chloroquine for retinal toxicity has not been established, careful, ongoing screening is required, especially as the cumulative dose increases.
S Bertagnolio; E Tacconelli; G Camilli; M Tumbarello
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  65     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-21     Completed Date:  2001-12-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  637-8     Citation Subset:  AIM; IM    
Department of Infectious Diseases, Catholic University, Rome, Italy.
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MeSH Terms
Antimalarials / adverse effects*
Chloroquine / adverse effects*
Malaria / prevention & control*
Middle Aged
Retinal Diseases / chemically induced*
Reg. No./Substance:
0/Antimalarials; 54-05-7/Chloroquine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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