| Case-only design to measure gene-gene interaction. | |
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MedLine Citation:
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PMID: 10069253 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The case-only design is an efficient and valid approach to screening for gene-environment interaction under the assumption of the independence between exposure and genotype in the population. In this paper, we show that the case-only design is also a valid and efficient approach to measuring gene-gene interaction under the assumption that the frequencies of genes are independent in the population. Just as the case-only design requires fewer cases than the case-control design to measure gene-environment interaction, it also requires fewer cases to measure gene-gene interactions. |
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Authors:
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Q Yang; M J Khoury; F Sun; W D Flanders |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Epidemiology (Cambridge, Mass.) Volume: 10 ISSN: 1044-3983 ISO Abbreviation: Epidemiology Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-04-22 Completed Date: 1999-04-22 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9009644 Medline TA: Epidemiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 167-70 Citation Subset: IM |
Affiliation:
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Division of Birth Defects and Developmental Disabilities, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Epidemiologic Studies* Genes* Humans Molecular Epidemiology* Odds Ratio Research Design |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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