Document Detail

Case of the month: March 1999--A 26 year old HIV positive male with dura based masses.
MedLine Citation:
PMID:  10416997     Owner:  NLM     Status:  MEDLINE    
A 26-year-old male with AIDS presented with a chief complaint of headaches and neck pain. An MRI revealed two enhancing extra-axial dura based masses, one in the area of the left sphenoid wing and one at the level of C2-3. In both cases, microscopic sections showed actin positive spindle cell neoplasms with long slender nuclei, consistent with leiomyomas. Both tumors were positive for Epstein Barr virus by in situ hybridization. This case report serves to emphasize the importance of considering soft tissue tumors such as leiomyoma in the differential diagnosis of mass lesions that occur in the central nervous system in AIDS and discusses the role of EBV in tumorigenesis.
N C Karpinski; R Yaghmai; D Barba; L A Hansen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Brain pathology (Zurich, Switzerland)     Volume:  9     ISSN:  1015-6305     ISO Abbreviation:  Brain Pathol.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-09-27     Completed Date:  1999-09-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9216781     Medline TA:  Brain Pathol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  609-10     Citation Subset:  IM; X    
Department of Pathology (Neuropathology), UCSD Medical Center, San Diego, CA, USA.
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MeSH Terms
Acquired Immunodeficiency Syndrome / complications*
Actins / metabolism
Brain Neoplasms / complications*,  metabolism,  pathology,  virology
Herpesvirus 4, Human / isolation & purification
In Situ Hybridization
Leiomyoma / complications*,  metabolism,  pathology,  virology
Magnetic Resonance Imaging
Meningeal Neoplasms / complications*,  metabolism,  pathology,  virology
Reg. No./Substance:

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