| Case of high-risk epithelioid hemangioendothelioma of the neck. | |
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MedLine Citation:
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PMID: 23019156 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Epithelioid hemangioendotheliomas (EHEs) of the head and neck region are uncommon malignant neoplasms that exhibit various biologic behaviors characteristic of both low- and high-grade malignancy. A subgroup of EHEs identified as "high-risk" EHEs because of their size and mitotic activity is associated with an unfavorable clinical course and poor prognosis. MATERIALS AND RESULTS: We describe the treatment of the first and, in terms of size, largest case of high-risk EHE arising from the neck. Despite wide excision, recurrence occurred 9 months after surgery, as had been expected. However, the tumor was found to express both vascular endothelial growth factor (VEGF) and VEGF receptor 2, indicating the potential of anti-VEGF therapy in the treatment of such cases. CONCLUSION: The finding that a high-risk EHE arising from the head and neck region is characterized by expression of VEGF and its receptor provides further support for the development of targeted molecular therapies. © 2012 Wiley Periodicals, Inc. Head Neck, 2012. |
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Authors:
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Shingo Matsuzawa; Takeharu Kanazawa; Takehiko Yamaguchi; Hiroshi Nishino; Kazumi Kawada; Keiichi Ichimura |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-28 |
Journal Detail:
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Title: Head & neck Volume: - ISSN: 1097-0347 ISO Abbreviation: Head Neck Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8902541 Medline TA: Head Neck Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Department of Otolaryngology/Head and Neck Surgery, Jichi Medical University School of Medicine, Shimotsuke Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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