Document Detail

Case fatality among infants with congenital malformations by lethality.
MedLine Citation:
PMID:  15368556     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Infant mortality rates continue to show that congenital anomalies are the leading cause of infant death in the United States. However, studies of factors contributing to increased mortality across different types of congenital anomalies have been limited. The objective of this study was to assess whether the likelihood of infant mortality varied by maternal race and ethnic group while considering the severity of the birth defect. METHODS: A retrospective cohort analysis was conducted using data from Colorado's statewide, population-based birth defects surveillance system (CRCSN). The cohort included infants, born between 1995 and 2000 to Colorado resident mothers, who were diagnosed with major congenital malformations stratified by degree of lethality. Multiple logistic regression was performed for each level of lethality, and included the following potential explanatory variables: maternal race/ethnicity, clinical gestation, birth weight, maternal education level, maternal age, and sex of child. RESULTS: Within the low/very low lethality cohort, maternal race/ethnicity of Black/non-Hispanic was associated with increased risk of infant mortality, OR 2.81 (1.41-5.19), as were low and very low birth weight, OR 2.21 (1.12-4.04) and 19.31 (11.84-31.01), respectively. Maternal race/ethnicity was not a significant risk factor in either high or very high lethality groups; however, the interaction between birth weight and gestational age significantly increased the risk of mortality. CONCLUSIONS: Through the use of statewide, population-based birth defects surveillance data, a disparity in infant mortality has been identified in a specific subset of the population that could be investigated further and targeted for prevention activities.
Kirk A Bol; Russel S Rickard; Russell S Kirby
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Birth defects research. Part A, Clinical and molecular teratology     Volume:  70     ISSN:  1542-0752     ISO Abbreviation:  Birth Defects Res. Part A Clin. Mol. Teratol.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-15     Completed Date:  2005-02-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101155107     Medline TA:  Birth Defects Res A Clin Mol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  580-5     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Wiley-Liss, Inc.
Colorado Responds to Children With Special Needs, Colorado Department of Public Health and Environment Denver 80246, USA.
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MeSH Terms
African Continental Ancestry Group
Cause of Death*
Cohort Studies
Colorado / epidemiology
Congenital Abnormalities / classification,  ethnology,  mortality*
European Continental Ancestry Group
Gestational Age
Hispanic Americans
Infant, Newborn
Odds Ratio
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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