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Case of endophthalmitis following intravitreal injections of bevacizumab.
MedLine Citation:
PMID:  20689793     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
PURPOSE: We report a case of infectious endophthalmitis that developed after the third intravitreal injection of bevacizumab. The endophthalmitis was caused by Staphylococcus epidermidis.
METHODS: Observational case series.
RESULTS: This was a case of a 77-year-old man who had received three intravitreal injections of bevacizumab and developed infectious endophthalmitis. Polymerase chain reaction of an aqueous humor sample showed that the endophthalmitis was caused by S. epidermidis. The patient received intravitreal ceftazidime and vancomycin, and subconjunctival injection of vancomycin. After the intravitreal injections he was treated with topical levofloxacin and cefmenoxime hydrochloride, and intravenous cefpirome. Subsequently, the ocular inflammation gradually decreased and his visual acuity remained at 30/200.
CONCLUSIONS: Our findings indicate that endophthalmitis can develop after intravitreal bevacizumab injections. Polymerase chain reaction is useful for differentiation from sterile endophthalmitis.
Authors:
Shinya Komori; Akira Sawada; Tsutomu Oguni; Kiyofumi Mochizuki; Kiyofumi Ohkusu
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Publication Detail:
Type:  Journal Article     Date:  2010-07-30
Journal Detail:
Title:  Clinical ophthalmology (Auckland, N.Z.)     Volume:  4     ISSN:  1177-5483     ISO Abbreviation:  Clin Ophthalmol     Publication Date:  2010  
Date Detail:
Created Date:  2010-08-06     Completed Date:  2011-06-29     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101321512     Medline TA:  Clin Ophthalmol     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  773-5     Citation Subset:  -    
Affiliation:
Department of Ophthalmology, Gifu University Graduate School of Medicine, Gifu-shi, Japan.
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