| Case-control study of teratogenic potential of thiethylperazine, an anti-emetic drug. | |
| | |
MedLine Citation:
|
PMID: 12742335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Thiethylperazine is a commonly used anti-emetic drug during pregnancy in Hungary. One experimental study in mice and rats found an increased occurrence of cleft palate after the use of thiethylperazine during pregnancy but the human data of thiethylperazine have not been reported. Thus, the aim of the study was to investigate the possible human teratogenic effect of thiethylperazine. DESIGN: Case-control approach. SETTING: The teratogenic potential of thiethylperazine was evaluated in the population-based large data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities between 1980 and 1996. SAMPLE: Of 38,151 newborn infants without any congenital abnormalities (control group), 746 (2.0%) had mothers who were treated with thiethylperazine, while of 22,843 cases with congenital abnormalities, 411 (1.8%) had mothers who were treated with thiethylperazine during pregnancy. METHODS: Case-control pair analysis. MAIN OUTCOME MEASURES: Different congenital abnormalities. RESULTS: The pairs of cases with congenital abnormalities and their matched controls without congenital abnormalities were compared and this approach showed a somewhat higher rate of cleft lip +/- palate (OR: 2.0 with 95% CI: 1.0-4.0) in infants born to mothers with thiethylperazine treatment during the first trimester of pregnancy. CONCLUSION: Our data do not indicate clear teratogenic effect of thiethylperazine, however, a weak association was found between thiethylperazine use and cleft lip +/- palate. |
| | |
Authors:
|
A E Czeizel; P Vargha |
Related Documents
:
|
14591415 - Handedness concordance and intelligence discrepancies in identical twins. 3451645 - Epidemiological characteristics of twinning rates in taiwan. 7871945 - Physical growth of japanese twins. 22519675 - Sperm chromatin integrity may predict future fertility for unexplained recurrent sponta... 14591415 - Handedness concordance and intelligence discrepancies in identical twins. 22207855 - Development of fetal movement between 26 and 36-weeks' gestation in response to vibro-a... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: BJOG : an international journal of obstetrics and gynaecology Volume: 110 ISSN: 1470-0328 ISO Abbreviation: BJOG Publication Date: 2003 May |
Date Detail:
|
Created Date: 2003-05-13 Completed Date: 2003-06-12 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 100935741 Medline TA: BJOG Country: England |
Other Details:
|
Languages: eng Pagination: 497-9 Citation Subset: AIM; IM |
Affiliation:
|
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abnormalities, Drug-Induced* Antiemetics / adverse effects* Case-Control Studies Cleft Palate / chemically induced* Female Humans Hungary Nausea / drug therapy Pregnancy Pregnancy Complications / drug therapy Thiethylperazine / adverse effects* Vomiting / drug therapy |
| Chemical | |
Reg. No./Substance:
|
0/Antiemetics; 1420-55-9/Thiethylperazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antenatal screening for human platelet antigen-1a: results of a prospective study at a large materni...
Next Document: Pathways to evidence-based reproductive healthcare in developing countries.