Document Detail

Case control study of cerebral perfusion deficits in divers using 99Tcm hexamethylpropylene amine oxime.
MedLine Citation:
PMID:  1746068     Owner:  NLM     Status:  MEDLINE    
In a preliminary report, Adkisson et al. (Lancet 1989; 2:119-121) used 99Tcm-hexamethylpropylene amine oxime (HMPAO) single photon emission computed tomography (SPECT) to provide evidence for cerebral perfusion deficits in 28 cases of dysbarism. The report caused concern because these deficits were found even in cases in which the clinical manifestations were limited to the spinal cord. To address this issue further, a case-control study of cerebral perfusion using 99Tcm-HMPAO SPECT is reported. Four groups of 10 subjects were studied: a) divers scanned on average 11 days after treatment of neurologic decompression illness, b) divers scanned 3-5 yr after treatment for neurologic decompression illness, c) diver controls, and d) population controls. All groups were matched for age, and the divers were further matched for general diving experience. The scans were randomized and reported blind to history. Despite a trend toward larger numbers of deficits in individuals with decompression illness, the 4 groups were statistically indistinguishable. Furthermore, no correlation was found between the location of the perfusion deficits and the clinical presentation. These results indicate that 99Tcm-HMPAO SPECT scanning requires further evaluation before clinical significance can be ascribed to perfusion deficits found in divers.
M Hodgson; D J Smith; M A Macleod; A S Houston; T J Francis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Undersea biomedical research     Volume:  18     ISSN:  0093-5387     ISO Abbreviation:  Undersea Biomed Res     Publication Date:    1991 Sep-Nov
Date Detail:
Created Date:  1992-01-16     Completed Date:  1992-01-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421514     Medline TA:  Undersea Biomed Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  421-31     Citation Subset:  IM; S    
Undersea Medicine Division, Institute of Naval Medicine, Gosport, Hants, England.
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MeSH Terms
Brain Diseases / etiology
Brain Ischemia / complications,  radionuclide imaging*
Case-Control Studies
Decompression Sickness / complications,  radionuclide imaging*
Organotechnetium Compounds / diagnostic use*
Oximes / diagnostic use*
Technetium Tc 99m Exametazime
Tomography, Emission-Computed, Single-Photon*
Reg. No./Substance:
0/Organotechnetium Compounds; 0/Oximes; 100504-35-6/Technetium Tc 99m Exametazime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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