| A case-control study of roles of diet in colorectal carcinoma in a South Indian Population. | |
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MedLine Citation:
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PMID: 19827870 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: The worldwide incidence of colorectal cancer has increased rapidly in the past few decades and dietary habits have been implicated in the cause. Though the Indian diet varies substantially from western diet, there have not been detailed studies on any association. MATERIALS AND METHODS: This is hospital based case control study enrolling 108 cases and 324 controls, all hailing from the Malabar region of Kerala, India. The subjects were interviewed using food frequency questionnaires for commonly consumed dietary items in the region. RESULTS: A strong association was found between colorectal cancer and tapioca (OR= 2.7 p= 0.001), beef (OR= 4.25, p= 0.000) and pungent spices (OR= 9.62, p= 0.018). Fruits and vegetables a showed strong inverse association (OR= 0.15 p= 0.002). Fish consumption on a daily basis showed a 25% reduction in risk on univariate analysis. Heavy consumption of sugar (OR= 2.80) and tobacco use (OR= 8.79) showed significant high risk. CONCLUSIONS: There is strong evidence from our study that intake of beef, refined carbohydrates and tobacco can promote colorectal cancer. Our study has also thrown light on some of the other commonly consumed items, like tapioca and spices, which have positive associations. These are commonly consumed in Malabar region of Kerala. A cohort study is now needed to confirm our findings. |
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Authors:
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Sandeep P Nayak; M P Sasi; M P Sreejayan; Syamsundar Mandal |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Asian Pacific journal of cancer prevention : APJCP Volume: 10 ISSN: 1513-7368 ISO Abbreviation: Asian Pac. J. Cancer Prev. Publication Date: 2009 Oct-Dec |
Date Detail:
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Created Date: 2009-10-15 Completed Date: 2009-11-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101130625 Medline TA: Asian Pac J Cancer Prev Country: Thailand |
Other Details:
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Languages: eng Pagination: 565-8 Citation Subset: IM |
Affiliation:
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Department of Surgical Oncology, Chittaranjan National Cancer Institute (CNCI), Kolkata, India. sandeepnayakp@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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epidemiology*,
prevention & control Adolescent Adult Aged Aged, 80 and over Case-Control Studies Colorectal Neoplasms / epidemiology*, prevention & control Diet* Female Food Habits* Humans Incidence India / epidemiology Male Middle Aged Neoplasm Staging Prognosis Risk Factors Survival Rate Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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