Document Detail

Case of chest-wall rigidity in a preterm infant caused by prenatal fentanyl administration.
MedLine Citation:
PMID:  20118943     Owner:  NLM     Status:  MEDLINE    
The inability to appropriately ventilate neonates shortly after their birth could be related in rare cases to chest-wall rigidity caused by the placental transfer of fentanyl. Although this adverse effect is recognized when fentanyl is administered to neonates after their birth, the prenatal phenomenon is less known. Treatment with either naloxone or muscle relaxants reverses the fentanyl effect and may prevent unnecessary excessive ventilatory settings.
S Eventov-Friedman; I Rozin; E S Shinwell
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  30     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-06-07     Revised Date:  2010-09-28    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  149-50     Citation Subset:  IM    
Department of Neonatology, Kaplan Medical Center, Rehovot, Israel.
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MeSH Terms
Cesarean Section
Fentanyl / adverse effects*
Infant, Newborn
Infant, Premature, Diseases / chemically induced*,  drug therapy
Muscle Rigidity / chemically induced*,  drug therapy
Naloxone / therapeutic use*
Narcotic Antagonists / therapeutic use
Narcotics / adverse effects*
Pregnancy Complications, Infectious
Pyelonephritis / complications
Respiratory Distress Syndrome, Adult / complications,  drug therapy*
Thoracic Wall* / drug effects
Reg. No./Substance:
0/Narcotic Antagonists; 0/Narcotics; 437-38-7/Fentanyl; 465-65-6/Naloxone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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