Document Detail

Case of adolescent with Paget-Schroetter syndrome and underlying thrombophilia due to an elevated lipoprotein (A).
MedLine Citation:
PMID:  16496286     Owner:  NLM     Status:  MEDLINE    
Upper extremity deep vein thrombosis (UEDVT) is a rare disorder in children and is most often associated with a central venous catheter (CVC), cancer, or an underlying thrombophilia. In adults, repetitive or strenuous upper extremity activity has been linked to mechanical compression of the thoracic outlet resulting in subclavian vein thrombosis, also known as Paget-Schroetter Syndrome (PSS). We present the case of a 14 year old female who was found to have an UEDVT consistent with PSS. On subsequent thrombophila screening, she was noted to have a significantly elevated lipoprotein (a) level of 83 (normal: <30 mg/dL). She underwent 3 months of anticoagulation therapy prior to her first rib resection and in follow-up was noted to have complete patency of her subclavian vein. This case illustrates the necessity for thrombophilia screening in the pediatric patient with UEDVT despite evidence of anatomic abnormality or mechanical venous compression.
J Dintaman; C Watson; C J Fox; N Hoover; S Roberts; D L Gillespie
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric blood & cancer     Volume:  49     ISSN:  1545-5009     ISO Abbreviation:  Pediatr Blood Cancer     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-10-22     Completed Date:  2007-12-06     Revised Date:  2009-01-12    
Medline Journal Info:
Nlm Unique ID:  101186624     Medline TA:  Pediatr Blood Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1036-8     Citation Subset:  IM    
Copyright Information:
2007 Wiley-Liss, Inc
Department of Pediatrics, National Capital Consortium, Washington, District of Columbia, USA.
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MeSH Terms
Anticoagulants / therapeutic use
Follow-Up Studies
Kidney Failure / complications,  diagnosis,  therapy
Lipoprotein(a) / blood*
Thrombectomy / methods
Thrombophilia / complications*,  diagnosis,  drug therapy
Treatment Outcome
Upper Extremity / pathology
Venous Thrombosis / complications*,  diagnosis,  drug therapy
Reg. No./Substance:
0/Anticoagulants; 0/Lipoprotein(a)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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