Document Detail

The case for routine parathyroid hormone monitoring.
MedLine Citation:
PMID:  23037984     Owner:  NLM     Status:  MEDLINE    
Parathyroid hormone (PTH) is a uremic toxin with multiple systemic effects including bone disorders (renal osteodystrophy), myopathy, neurologic abnormalities, anemia, pruritus, and cardiomyopathy. Hyperparathyroidism is common in CKD and results in significant morbidity and mortality if left untreated. Clinical practice guidelines from the Kidney Disease Improving Global Outcomes initiative broadened the optimal PTH range to >2 and <9 times the upper limit of normal for the assay measured. Furthermore, the guidelines recommend following trends in PTH to determine the appropriate therapy. These guidelines overcome issues with the assay variability and help clinicians make judgments when treating individual patients. They also require frequent measurement in order to determine trends and implement appropriate treatments.
Stuart M Sprague; Sharon M Moe
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-04
Journal Detail:
Title:  Clinical journal of the American Society of Nephrology : CJASN     Volume:  8     ISSN:  1555-905X     ISO Abbreviation:  Clin J Am Soc Nephrol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-08     Completed Date:  2013-08-12     Revised Date:  2014-02-16    
Medline Journal Info:
Nlm Unique ID:  101271570     Medline TA:  Clin J Am Soc Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  313-8     Citation Subset:  IM    
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MeSH Terms
Diagnostic Tests, Routine
Hematologic Tests / utilization
Parathyroid Hormone / blood*
Renal Insufficiency, Chronic / blood*
Grant Support
Reg. No./Substance:
0/Parathyroid Hormone
Comment In:
Clin J Am Soc Nephrol. 2013 Feb;8(2):319-20   [PMID:  23160263 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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