Document Detail

A case report of T cell prolymphocytic leukemia and Kaposi sarcoma and a review of T cell prolymphocytic leukemia.
MedLine Citation:
PMID:  22517037     Owner:  NLM     Status:  MEDLINE    
T cell prolymphocytic leukemia (T-PLL) is a rare mature T cell lymphoproliferative disease. It has been associated with an aggressive course, a poor response to conventional chemotherapy and a short median survival. Here we present a rare case of concurrent T-PLL and Kaposi sarcoma who achieved a complete hematologic and cytogenetic remission after a very short course of treatment with alemtuzumab. A review of T-PLL was done. In this review, clinical features, laboratory features and current therapeutic strategies of T-PLL are presented.
R N Paul; L Alizadeh; O I Ajayi; H Karpurapu; C Ganesan; L Taddesse-Heath; A Aggarwal
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2012-04-13
Journal Detail:
Title:  Acta haematologica     Volume:  127     ISSN:  1421-9662     ISO Abbreviation:  Acta Haematol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-15     Completed Date:  2012-07-11     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  235-43     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Division of Hematology/Oncology, Department of Medicine, Howard University Hospital, Washington, DC 20060, USA.
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MeSH Terms
Aged, 80 and over
Antibodies, Monoclonal, Humanized / therapeutic use
Antigens, CD
Antigens, Neoplasm
Antineoplastic Agents / therapeutic use
Glycoproteins / antagonists & inhibitors
Leukemia, Prolymphocytic, T-Cell / diagnosis,  immunology,  therapy*
Neoplasms, Multiple Primary / diagnosis,  immunology,  therapy*
Remission Induction
Sarcoma, Kaposi / radiotherapy,  therapy*
Time Factors
Reg. No./Substance:
0/Antibodies, Monoclonal, Humanized; 0/Antigens, CD; 0/Antigens, Neoplasm; 0/Antineoplastic Agents; 0/CD52 antigen; 0/Glycoproteins; 3A189DH42V/alemtuzumab

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