Document Detail


Case report: hypophosphatemic rickets and aggressive periodontitis: a review of the role of dentine matrix protein 1 in the pathogenesis.
MedLine Citation:
PMID:  21299946     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The association between hypophosphatemic rickets (HR) and excessive periodontal breakdown was reported in mice models of HR. In humans, this is the first report of a possible association between HR and periodontal breakdown.
CASE REPORT: The following presents a report of a case of a 15 yearold child diagnosed with HR at age 9 years, with atypical premature spontaneous loss of teeth due to periodontal defects in the absence of dental abscesses, dental caries, or trauma. The case is discussed in the context of relevant literature; the possible role of dentine matrix protein 1 in the aetiology of such periodontal defects in patients with HR is also discussed.
CONCLUSION: Spontaneous loss of teeth in the absence of abscess formation is not one of the reported features of HR, however, this report may alert clinicians of the possibility of such association especially in the autosomal recessive type. Further case reports and more elaborate genetic and molecular testing is needed to verify this especially in late diagnosis cases.
Authors:
S H Al-Jundi; M M Hammad; I Dabous
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry     Volume:  12     ISSN:  1818-6300     ISO Abbreviation:  Eur Arch Paediatr Dent     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-08     Completed Date:  2011-05-10     Revised Date:  2011-10-21    
Medline Journal Info:
Nlm Unique ID:  101277157     Medline TA:  Eur Arch Paediatr Dent     Country:  England    
Other Details:
Languages:  eng     Pagination:  46-50     Citation Subset:  D; IM    
Affiliation:
Department Preventive Dentistry, Jordan University of Science and Technology, Irbid. aljundisuhad@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Aggressive Periodontitis / complications*,  genetics*
Consanguinity
Extracellular Matrix Proteins / genetics*
Humans
Hypophosphatemic Rickets, X-Linked Dominant / complications*,  genetics*
Male
Mutation
Phosphoproteins / genetics*
Chemical
Reg. No./Substance:
0/DMP1 protein, human; 0/Extracellular Matrix Proteins; 0/Phosphoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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