| A case of primary histiocytic sarcoma arising from thyroid gland. | |
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MedLine Citation:
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PMID: 19655275 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Histiocytic sarcoma (HS) is an extremely rare true histiocytic malignancy. We report a case of HS arising from thyroid gland in a 69 year-old man. Following subtotal thyroidectomy, a histopathologic, immunohistologic, and genotypic examination revealed HS. This tumor was composed of large spindle or round epithelioid cells with abundant eosinophilic cytoplasm. The neoplastic cells were positive for macrophage-associated antigen CD68, CD163, and lysozymes, as well as CD45, HLA- DR, DP, DQ, and S100, most consistent with a diagnosis of HS. The BIOMED-2 multiplex PCR analysis showed polyclonal B- and T-cell populations. To our knowledge, this is the first report of a rare entity HS involving thyroid gland using a comprehensive immunophenotyping panel including CD163 as well as molecular studies to establish the true histiocytic nature of these lesions. |
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Authors:
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Lu Yu; Shou Jing Yang |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-08-05 |
Journal Detail:
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Title: Pathology oncology research : POR Volume: 16 ISSN: 1532-2807 ISO Abbreviation: Pathol. Oncol. Res. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-11 Completed Date: 2010-06-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9706087 Medline TA: Pathol Oncol Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 127-32 Citation Subset: IM |
Affiliation:
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Department of Pathology, Xi Jing Hospital, 4th Military Medical University, No. 17 Chang Le Xi Road, Xi'an, Shaanxi, 710032, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Histiocytic Sarcoma / metabolism, pathology*, surgery Humans Immunohistochemistry Immunophenotyping Male Thyroid Neoplasms / metabolism, pathology*, surgery Thyroidectomy Tumor Markers, Biological / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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