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A Case of Microscopic Polyangiitis Following Mycoplasma Infection in a Patient with MPO-ANCA Positive Pulmonary Fibrosis.
MedLine Citation:
PMID:  21099250     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Microscopic polyangiitis is a vasculitic disease that may result in a pulmonary renal syndrome. Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis is strongly associated with infection. Case Summary: We describe a case of microscopic polyangiitis that developed in a patient with MPO-ANCA positive pulmonary fibrosis following infection with mycoplasma. A renal biopsy was undertaken following the detection of microscopic hematuria during follow-up but no abnormal findings were evident. The MPO-ANCA titer increased following infection with mycoplasma pneumonia and a second renal biopsy demonstrated crescentic glomerulonephritis. The degree of pulmonary fibrosis was unaffected. Discussion: The present case suggests that the mycoplasma infection triggered the elevation of MPO-ANCA titer and provoked glomerulonephritis in a patient with MPO-ANCA positive IPF. This case indicates the importance of testing for MPO-ANCA at the time of initial diagnosis, performing urinalysis and examining the urine sediment during follow-up and being alert to the potential onset of vasculitis in cases of pulmonary fibrosis.
Authors:
Hazuki Takato; Masahide Yasui; Yuko Waseda; Nobuhiko Sakai; Takashi Wada; Masaki Fujimura
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-11-24
Journal Detail:
Title:  Allergology international : official journal of the Japanese Society of Allergology     Volume:  60     ISSN:  1440-1592     ISO Abbreviation:  Allergol Int     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616296     Medline TA:  Allergol Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Hospital, Ishikawa.
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