Document Detail


A Case of Long-term Remission with Ofatumumab Maintenance-Therapy in Multiply Relapsed and Rituximab-Refractory Chronic Lymphocytic Leukaemia with Deletion 17p.
MedLine Citation:
PMID:  23278160     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We report a 77-year old male patient with chronic lymphocytic leukaemia (CLL), requiring the sixth line of treatment due to relapse with progressive lymphadenopathy, worsening thrombocytopenia and pronounced night sweats. First diagnosis was established 8 years earlier in 2004 with advanced stage disease (Binet C) and a high risk profile consisting in high CD38 and ZAP70 expression. Initial fluorescence-in-situ-hybridization showed deletion 13q in 65% of CLL-cells without other chromosomal aberrations. Previous CLL specific therapies are summarized in table 1. © 2012 John Wiley & Sons A/S.
Authors:
Namberger Konrad; Weiss Lukas; Krause Barbara; Melchardt Thomas; Greil Richard
Publication Detail:
Type:  LETTER     Date:  2012-12-28
Journal Detail:
Title:  European journal of haematology     Volume:  -     ISSN:  1600-0609     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-1-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
3rd Medical Department of Haematology, Medical Oncology, Haemostaseology, Rheumatology and Infectious Disease, University Hospital Salzburg, Salzburg, Austria.
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