| A case of ischemic stroke in acute promyelocytic leukemia at initial presentation. Relevance of all-trans retinoic acid treatment. | |
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MedLine Citation:
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PMID: 20041837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute promyelocytic leukemia (APL) is frequently associated, often from the earliest phases, with a life-threatening coagulation/bleeding syndrome; disseminated intravascular coagulation (DIC) is described in majority of patients. We report a case of 49-year-old male, without cardiovascular risk factors, who suddenly developed ischemic stroke and splenic infarction as presenting symptoms of APL and related DIC. The patient was immediately treated with all-trans retinoic acid (ATRA) and the alterations of hemocoagulation parameters promptly returned in normal range. The coagulation/bleeding syndrome of the onset of APL is associated with high mortality; both diagnostic and therapeutic approaches require special and timely consideration of this condition. Treatment with ATRA is essential. |
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Authors:
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Angelo M Carella; Giuseppe Antonucci; Matteo Conte; Michele Di Pumpo; Elisabetta Antonucci; Ernestina Ponziano |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Cardiovascular & hematological disorders drug targets Volume: 10 ISSN: 1871-529X ISO Abbreviation: Cardiovasc Hematol Disord Drug Targets Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-19 Completed Date: 2010-06-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101269160 Medline TA: Cardiovasc Hematol Disord Drug Targets Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1-6 Citation Subset: IM |
Affiliation:
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Internal Medicine Department of T. Masselli-Mascia Hospital - San Severo (Fg), Italy. mic.carella@virgilio.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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therapeutic use Disseminated Intravascular Coagulation / drug therapy*, etiology Humans Leukemia, Promyelocytic, Acute / blood, complications, drug therapy* Male Middle Aged Stroke / drug therapy*, etiology Tretinoin / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 302-79-4/Tretinoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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