Document Detail


Case-control study of neurodevelopment in deformational plagiocephaly.
MedLine Citation:
PMID:  20156894     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We assessed the neurodevelopment of infants with and without deformational plagiocephaly (DP), at an average age of 6 months.
METHODS: The Bayley Scales of Infant Development III (BSID-III) were administered to 235 case subjects and 237 demographically similar, control participants. Three-dimensional head photographs were randomized and rated for severity of deformation by 2 craniofacial dysmorphologists who were blinded to case status.
RESULTS: We excluded 2 case subjects with no photographic evidence of DP and 70 control subjects who were judged to have some degree of DP. With control for age, gender, and socioeconomic status, case subjects performed worse than control subjects on all BSID-III scales and subscales. Case subjects' average scores on the motor composite scale were approximately 10 points lower than control subjects' average scores (P < .001). Differences for the cognitive and language composite scales were approximately 5 points, on average (P < .001 for both scales). In subscale analyses, case subjects' gross-motor deficits were greater than their fine-motor deficits. Among case subjects, there was no association between BSID-III performance and the presence of torticollis or infant age at diagnosis.
CONCLUSIONS: DP seems to be associated with early neurodevelopmental disadvantage, which is most evident in motor functions. After follow-up evaluations of this cohort at 18 and 36 months, we will assess the stability of this finding. These data do not necessarily imply that DP causes neurodevelopmental delay; they indicate only that DP is a marker of elevated risk for delays. Pediatricians should monitor closely the development of infants with this condition.
Authors:
Matthew L Speltz; Brent R Collett; Marni Stott-Miller; Jacqueline R Starr; Carrie Heike; Antigone M Wolfram-Aduan; Darcy King; Michael L Cunningham
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-02-15
Journal Detail:
Title:  Pediatrics     Volume:  125     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-02     Completed Date:  2010-04-05     Revised Date:  2013-03-27    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e537-42     Citation Subset:  AIM; IM    
Affiliation:
Seattle Children's Hospital, 4800 Sand Point Way, N.E., Mailstop W-3636, Seattle, WA 98105, USA. mspeltz@u.washington.edu
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Child Development*
Female
Humans
Infant
Male
Plagiocephaly, Nonsynostotic / complications,  physiopathology*
Severity of Illness Index
Torticollis / etiology,  physiopathology
Grant Support
ID/Acronym/Agency:
1 R01 HD046565/HD/NICHD NIH HHS; 1 UL1 RR025014/RR/NCRR NIH HHS; M01 RR000037/RR/NCRR NIH HHS; R01 HD046565/HD/NICHD NIH HHS
Comments/Corrections
Comment In:
J Pediatr. 2010 Sep;157(3):514-5   [PMID:  20727446 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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