| Case-Control Study of Cutaneous Human Papillomavirus Infection in Basal Cell Carcinoma of the Skin. | |
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MedLine Citation:
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PMID: 23303448 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Genus-β human papillomavirus (HPV) DNA has been detected in basal cell carcinoma (BCC) tumors, but most epidemiologic studies have not observed associations between genus-β HPV seropositivity and BCC. A clinic-based case-control study was conducted to investigate cutaneous HPV infection in BCC. BCC cases (n=224) were recruited from a dermatology clinic, and controls (n=300) were patients who were screened negative for skin cancer. Antibodies against cutaneous HPV types in genera α, β, γ, mu, and nu were measured, and tumors from a subset of BCC cases (n=195) were tested for HPV DNA. Overall associations were observed between BCC and seropositivity for HPV types in genus-α (odds ratio (OR)=1.61; 95% confidence interval (CI)=1.11-2.35), γ (OR=1.78; 95% CI=1.22-2.60), and mu (OR=1.56; 95% CI=1.06-2.30). BCC cases with β-HPV DNA in their tumors were more likely to be β-HPV seropositive than controls (OR=1.76; 95% CI=1.03-3.01), with type-specific associations observed for HPV8 and HPV23, whereas no association was observed between β-HPV seropositivity and β-HPV DNA-negative BCC. No concordance between seropositivity and tumor DNA status was observed for HPV types in genera α and γ. In conclusion, the combined serology and tumor DNA results suggest that β HPV types may have a role in BCC. Additional studies of BCC that assess HPV types in multiple genera are needed.Journal of Investigative Dermatology advance online publication, 10 January 2013; doi:10.1038/jid.2012.478. |
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Authors:
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Michelle R Iannacone; Tarik Gheit; Tim Waterboer; Anna R Giuliano; Jane L Messina; Neil A Fenske; Basil S Cherpelis; Vernon K Sondak; Richard G Roetzheim; Sandra Ferrer-Gil; Kristina M Michael; Sandrine McKay-Chopin; Michael Pawlita; Massimo Tommasino; Dana E Rollison |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-10 |
Journal Detail:
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Title: The Journal of investigative dermatology Volume: - ISSN: 1523-1747 ISO Abbreviation: J. Invest. Dermatol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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