| A case of Churg-Strauss syndrome with necrotizing crescentic glomerulonephritis accompanied by acute coronary syndrome due to vasospasm. | |
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MedLine Citation:
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PMID: 20537776 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a case of Churg-Strauss syndrome coexistent with coronary vasospasm and pauci-immune necrotizing crescentic glomerulonephritis. A 54-year-old man with bronchial asthma and allergic rhinitis was admitted to our hospital because of acute coronary syndrome. Angiography showed diffuse coronary artery spasm without anatomic stenosis. Acute coronary syndrome due to vasospasm was diagnosed. However, subsequent administration of vasodilators did not suppress angina symptoms. In addition, marked eosinophilia, eosinophilic pneumonitis, chronic sinusitis, pericardial effusion, and slight hematuria with red blood cell casts were detected. Although kidney function was normal, a kidney biopsy showed necrotizing crescentic glomerulonephritis with eosinophilic infiltration in both glomeruli and interstitium. With the diagnosis of Churg-Strauss syndrome, oral prednisolone at a dose of 60 mg/d was administered. Cardiac symptoms, pulmonary and sinonasal lesions, pericardial effusion, and urine sediment resolved rapidly. Six months later, a repeated kidney biopsy showed remarkable improvement and no eosinophilic infiltration. Coronary vasospasm with eosinophilia might be refractory to vasodilators and sensitive to corticosteroid therapy and often has been related to Churg-Strauss syndrome. Slight abnormalities in urine sediment can be the clue to the diagnosis of severe kidney involvement of Churg-Strauss syndrome. |
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Authors:
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Mototsugu Tanaka; Naobumi Mise; Noriaki Kurita; Takeshi Suzuki; Kazuhiro Hara; Akiko Fujii; Noriko Uesugi; Tokuichiro Sugimoto |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 56 ISSN: 1523-6838 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-27 Completed Date: 2010-08-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: United States |
Other Details:
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Languages: eng Pagination: e5-9 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Nephrology, Department of Medicine, Mitsui Memorial Hospital, Tokyo, Japan. motanaka@mitsuihosp.or.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome
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complications*,
etiology Churg-Strauss Syndrome / complications*, pathology Coronary Vasospasm / complications* Eosinophilia / epidemiology Glomerulonephritis / complications*, diagnosis, pathology Glucocorticoids / therapeutic use Humans Kidney / pathology Male Middle Aged Necrosis Prednisolone / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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