Document Detail

Cascara sagrada-induced intrahepatic cholestasis causing portal hypertension: case report and review of herbal hepatotoxicity.
MedLine Citation:
PMID:  11151906     Owner:  NLM     Status:  MEDLINE    
Herbal medicines are gaining widespread popularity. Much of the public believes that botanical herbs are both harmless and useful for the treatment of a variety of symptoms. This belief stands in contrast with the fact that many herbal therapies have been shown to be toxic. In the present case report, cascara sagrada (CS) has been associated with the development of cholestatic hepatitis, complicated by portal hypertension. CS is a mixture of ingredients, among which is anthracene glycoside--an herbal agent that previously has been associated with chronic hepatitis. The liver injury in the case herein reported is believed to be related to either anthracene glycoside or one of the other constituents of CS.
A Nadir; D Reddy; D H Van Thiel
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  95     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-01-09     Completed Date:  2001-02-01     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3634-7     Citation Subset:  IM    
Division of Gastroenterology, Texas Tech University Health Science Center, USA.
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MeSH Terms
Cascara / adverse effects*
Cathartics / adverse effects*
Cholestasis, Intrahepatic / chemically induced*,  complications*,  pathology
Drug-Induced Liver Injury / etiology*,  pathology
Hypertension, Portal / etiology*,  pathology
Liver / drug effects,  pathology
Middle Aged
Reg. No./Substance:
0/Cathartics; 8047-27-6/Cascara

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